Drug discovery > Target Discovery Products & Reviews

Gene silencing in difficult-to-transfect cells guaranteed

Tailored transfection reagents for a wide variety of RNA and cells. High-efficiency delivery, low cellular toxicity, broad dynamic range

Crucial to any gene silencing or microRNA modulation experiment.  RNAi controls allow accurate interpretation for reliable, reproducible results.

Successful gene silencing in your cells of interest

Tightly controlled gene silencing with the most advanced and flexible single-vector inducible shRNA.

A direct and efficient set of tools to study a gene’s function by overexpression in its native context

Tissue Solutions is a leading global provider of ethically sourced human tissue samples used in all areas of drug discovery, research and development. ISO 9001:2015 certified and twice winner of the coveted Queens Award for Enterprise, Tissue Solutions offer a single point of access for a wide range of diseased and normal tissues in fresh, frozen, and FFPE formats.

HistologiX is a leading GLP/GCP accredited Contract Research Organisation based in the UK specialising in Histology, Immunohistochemistry (IHC) and Digital Pathology services. HistologiX works with a broad range of clients from big pharma to small and medium biotech companies worldwide. Our team of scientists have in excess of 120 years combined experience and a customer retention rate of 80%. 

HistologiX is a leading GLP/GCP accredited Contract Research Organisation based in the UK specialising in Histology, Immunohistochemistry (IHC) and Digital Pathology services. HistologiX works with a broad range of clients from big pharma to small and medium biotech companies worldwide. Our team of scientists have in excess of 120 years combined experience and a customer retention rate of 80%. 

Reliable in vivo breath sample collection of VOCs and respiratory droplets for biomarker identification and validation. Suitable for use in a range of contexts and diverse applications including early detection, drug development and precision medicine for conditions including respiratory diseases, liver diseases and cancer. Compatible with a range of analytical systems including GC-MS analysis with Breath Biopsy Services.

Combining high resolution accurate mass mass spectrometry and world-leading breath analysis expertise to offer complete breath biomarker discovery and validation solutions. Breath Biopsy Services provide versatile Breath Biopsy sample analysis and reporting driven by GC-Orbitrap technology and supported by a rigorous quality assurance process ensuring reliable, high sensitivity VOC biomarker detection.

Exogenous volatile organic compound probes (EVOC Probes) enable targeted, non-invasive assessment of biological pathways. Probes are safe, easy to administer compounds that interact with characterised metabolic pathways with relevance to key disease areas. Using Breath Biopsy, EVOC Probes can be monitored non-invasively on breath, either alone or in parallel with biomarker discovery studies.

A targeted panel of compounds with established relevance for respiratory diseases enabling high confidence, non-invasive disease detection and monitoring. Each compound is supported by evidence from breath research studies of relevant respiratory diseases and disease processes. The panel is available as an aspect of Breath Biopsy Services and panels for other disease applications are in development.

Identify prospective biomarkers relevant to key disease processes through in vitro GC-MS analysis. Compatible with headspace sampling from cell cultures, macromolecular preparations and ex vivo samples. Driven by GC-Orbitrap high-resolution mass spectrometry and supported by a rigorous and comprehensive quality assurance process. Results are suitable for comparison with in vivo studies using Breath Biopsy Services.

Consumable components of the Breath Biopsy system, required for robust breath sample collection using the ReCIVA Breath Sampler as part of the Breath Biopsy Collection Station. One Kit per sample.

Reliable and reproducible, non-invasive Breath Biopsy sample collection for high-accuracy analysis of human breath. ReCIVA provides high quality sample collection alongside ease-of-use and patient safety and comfort.  Samples are easy to store and transport and can be analysed using a wide range of techniques. We recommend processing Breath Biopsy samples using high-accuracy GC-MS, available through Breath Biopsy Services.

A versatile and easy to use analyzer for the detection of biomarkers in clinical samples using field asymmetric ion mobility spectrometry (FAIMS). Rapid, portable, sensitive and selective, Lonestar has wide-ranging applications for the detection and quantification of volatile organic compounds (VOCs) from a variety of sample types including feces, urine and breath.

The Qubit 1X dsDNA BR (Broad-Range) Assay Kit, when used with the Qubit Fluorometer, provides an accurate and selective method for the quantitation of DNA samples. The "1X" indicates a ready-to-use working solution, eliminating pipetting steps.

The Qubit RNA XR (Extended Range) Assay Kit, designed for use with the Qubit 4 and Qubit Flex fluorometers, provides an accurate and selective method for the quantitation of high-abundance RNA samples.

Easy setup directly on your microscope: perform live cell imaging in dishes, slides, or multiwell plates. The ibidi Stage Top Incubation Systems fit every standard inverted microscope and include CO 2 and O 2 control as well as actively controlled humidity. They are ideal for all live cell imaging applications and available for single slides and dishes as well as for multiwell plates.

Use this versatile 35 mm imaging Dish for high-end microscopy through the #1.5 coverslip bottom.

Use this high-quality rat tail collagen type I solution for cell culture applications (e.g., 3D gels, scaffolds, and coating).

Use this Multiwell plate with black walls, square wells, and a flat and clear coverslip bottom (#1.5 ibidi Polymer Coverslip) for high-throughput applications in cell-based assays. Also available with 24 wells.

Use this channel microscopy slide with a coverslip bottom (#1.5 ibidi Polymer or #1.5H glass) for immunofluorescence, cell culture under flow, live cell imaging, and high resolution microscopy on inverted microscopes. Available in various channel heights.

Use these silicone inserts with a defined cell-free gap for wound healing assays, migration assays, 2D invasion assays, and co-cultivation of cells. Available with 2, 3, or 4 wells.