Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
Cell Line-Derived Xenograft Models, Established multiple in vivo assay systems to evaluate novel anticancer compounds, with each assay specifically designed to understand a drug's mechanism of action, or an individual agent property.
Sirius T3 measures pKa, log P, and the solubility of ionizable drugs and small molecules using sub-milligram quantities of samples.
Biotinylated Human TNF-alpha, His, Avitag (TNA-H82E3) is expressed from human 293 cells (HEK293). It carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™), and has a calculated MW of 20.0 kDa. The protein migrates as 21 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
The Gyrolab® Mouse IFN-gamma Kit enables rapid quantification of murine IFN-gamma in serum samples
Machine-learning software that reduces the analysis bottleneck of large data sets in your surface plasmon resonance workflow
FITC-Labeled Human GPRC5D Full Length Protein, Flag,His Tag (GPD-HF2D6) is expressed from human 293 cells (HEK293). This protein carries a Flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.9 kDa.
Delve into biomarker discovery and drug development with Crown Bioscience’s next-generation proteomics services—leveraging 4D-DIA technology for deep, reproducible protein profiling and post-translational modification analysis.
Human Claudin-18.2 Full Length Protein-VLP (CL2-H52P7) is expressed from human 293 cells (HEK293). Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures.
Human VEGF165, His Tag (VE5-H5248) is expressed from human 293 cells (HEK293). It carries a polyhistidine tag at the N-terminus, and has a calculated MW of 21.1 kDa. The protein migrates as 27-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Unlock immune insights with Crown Bioscience’s high-throughput flow cytometry—precisely characterize immune cell populations across tissues to elucidate drug mechanisms, assess pharmacodynamics, and optimize immunotherapies.
Pion’s PAMPA high-throughput permeability assay uses a range of membranes to mimic physiologic conditions. It allows you to evaluate the passive permeability of API’s as well as the absorption potential of simple or complex formulations using robust models and protocols in a 96-well format.
Sf9 HCP 3G Solution for Gyrolab for the detection of Sf9 host cell protein impurities in bioprocess samples.
E.Coli HCP 2G Solution for Gyrolab enables detection of E. coli HCP impurities in products manufactured by recombinant expression.
Accelerate the development of your immuno-oncology drugs with Crown Bioscience’s large panel of immunocompetent syngeneic models.
The Gyrolab® Mouse IL-6 Kit enables rapid quantification of murine IL-6 in serum samples
Crown Bioscience’s preclinical biomarker services help identify, validate, and analyze biomarkers across diverse in vitro and in vivo cancer models. Using multi-omics platforms and expert bioinformatics, these services support drug mechanism studies, patient stratification, and companion diagnostic development to guide oncology drug discovery.
The Gyrolab® Mouse IL-10 Kit enables rapid quantification of murine IL-10 in serum samples
Human TNF-alpha Protein, His Tag (TNA-H5228) is expressed from human 293 cells (HEK293). It carries a polyhistidine tag at the C-terminus, and has a calculated MW of 18.3 kDa. The protein migrates as 17-19 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Biotinylated Human VEGF165, His,Avitag(VE5-H82Q0) is expressed from human 293 cells (HEK293). It carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™), and has a calculated MW of 22.4 kDa (monomer). The protein migrates as 25-33 kDa (monomer) under reducing (R) condition, and 42-55 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Gyrolab® Bioaffy™ 4000, the newest member of the Gyrolab Bioaffy family, offers 2-6 fold extended sensitivity for PK and biomarker analysis compared to Gyrolab Bioaffy 1000.
PDX Models Empower your research with models that reflect today’s patients and treatments.
Weigh, image and mark glass and plastic vials, all in one compact benchtop unit - this is MultiVial. Modular & configurable to your exact requirements, this versatile system offers fast and efficient processing of vials for your lab.
The SCISSOR is an in-vitro subcutaneous injection site simulator that provides biopharma scientists insights into the behavior of their sub-Q drug candidates.
Unlock deeper insights into tissue organization and cellular interactions with Crown Bioscience’s spatial biology and digital pathology services, featuring advanced imaging, automated analysis, and high-throughput biomarker screening for applications in cancer research, immunology, and more.
