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LiChrospher® DIOL is a versatile HPLC sorbent based on spherical silica particles possessing both polar and hydrophobic properties. LiChrospher® DIOL may be used as weakly hydrophobic sorbent in reversed phase chromatography with some limitations or as polar sorbent in normal phase chromatography. LiChrospher® DIOL is also suitable for exclusion chromatography.
A versatile sorbent for both reversed phase and straight phase chromatography: LiChrospher® NH2 is a versatile HPLC sorbent based on spherical silica particles possessing both polar and hydrophobic properties. LiChrospher® NH2 may be used for normal phase chromatography, reversed phase chromatography and for ion exchange chromatography. Typical applications are the separation of carbohydrates (mono-, di- and oilgosaccharides)…
A new member of the HyPURITY® family introduced at Pittcon 2003, HyPURITY AQUASTAR™ columns are a new silica-based polar end-capped C18 which is designed to offer superior retention of polar compounds and increased sensitivity in 100% aqueous conditions. The robust nature of the bonded phase results in a silica-based column that is unsurpassed for LC and LC/MS applications. This next generation column also offers enhanced perf…
LiChrospher® PAH is a highly efficient and selective HPLC column especially designed for the high resolution separation of 16 PAH (polycyclic aromatic hydrocarbons) according to EPA 610 and 550 + benzo(e)pyrene + perylene. LiChrospher® PAH is based on a special modified RP-18 silica gel to achieve highly resolved PAH separations. LiChrospher® PAH can be used for both, the isocratic separation of 6 PAH according to the German…
The Vision diode array spectrophotometer offers 16 predefined methodologies for nucleic acid quantification (DNA, RNA, and oligonucleotides), protein assays (BCA, Biuret, Bradford, and Lowry) and for cell culture density measurements. Additionally, the Vision can accomodate up to 90 custom protocols. The visualization of the nucleic acid scan with the full graphic display is particularly useful, especially for RNA samples wh…
The ASIC1a gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC1a channels expressed in neurons are therapeutic targets for treatment of pain and depression. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 ce…
The ACCN1 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC2a channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN1 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…
The ACCN31 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC3 channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…
Human Cav2.2/β3/α2δ1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4159. Three vials of Cyropreserved irradiated cells, 2x10E6 cells/vial (6x10E6 cells total). Platform validation: PatchXpress®
The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain. Synonyms: N-type calcium channel Host cell: CHO-K1, division-arrested Gene name: CACNA1B/CACNB3/CACNA2D1 My…
The HCN4 gene encodes the pore-forming subunit of a hyperpolarization-gated, cyclic nucleotide-sensitive, non-selective cation channel. HCN4 channels expressed in the heart contribute to the pacemaker current (Ih) and are therapeutic targets for treatment of cardiac ischemia and angina. Synonyms: hyperpolarization-activated, cyclic nucleotide-gated channel Host cell: CHO-K1, division-arrested Gene name: HCN4 Mycoplasma status…
The human KCNA3 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Kv1.3 channels expressed in lymphocytes are therapeutic targets in autoimmune diseases. Synonyms: hKv1.3 Host cell: CHO-K1, division-arrested Gene name: KCNA3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expressed in the heart are safety targets in congenital and acquired long QT syndromes. Synonyms: Kv7.1/minK Host cell: CHO-K1, division-arrested Gene name: KCNQ1/KCNE1 Mycoplasma status: Negative (M…
The human KCNQ4 gene encodes the pore-forming subunit of a voltage-gated potassium channel. KCNQ4 channels expressed in CNS neurons are therapeutic targets in epilepsy. Synonyms: Kv7.4 Host cell: CHO-K1, division-arrested Gene name: KCNQ4 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteris…
The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia). Synonyms: Kv11.1 Host cell: CHO-K1, division-arrested Gene name: KCNH2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Thr…
The human SCN1A gene encodes the pore-forming subunit of voltage-gated type-1 Na+ channels. Neuronal Nav1.1 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-1 sodium channel Host cell: CHO-K1 Gene name: SCN1A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth char…
The human Nav1.2 gene encodes the pore-forming subunit of voltage-gated type-2 Na+ channels. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-2 sodium channel Host cell: CHO-K1 Gene name: SCN2A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth cha…
The SCN3A gene encodes the pore-forming subunit of the voltage-gated type-3 Na+ channel. Neuronal Nav1.3 channels are therapeutic targets in seizure and pain. Synonyms: brain type-3 sodium channel Host cell: CHO-K1, division-arrested Gene name: SCN3A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia. Synonyms: Skeletal muscle sodium channel, SkM1 Host cell: CHO-K1, division-arrested Gene name: SCN4A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS…
The human Nav1.5 gene encodes the pore-forming subunit of the voltage-gated, cardiac Na+ channel. Nav1.5 is an antiarrhythmic therapeutic target. Synonyms: cardiac sodium channel Host cell: CHO-K1 Gene name: SCN5A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells remain viab…
The SCN8A gene encodes the pore-forming subunit of a voltage-gated Na+ channel. Neuronal Nav1.6 channels are therapeutic targets in pain treatment. Synonyms: NaCh6, PN4 Host cell: CHO-K1, division-arrested Gene name: SCN8A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells rema…
The human Nav1.7 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in sensory and sympathetic neurons. The Nav1.7 channel is a therapeutic target in pain treatment. Synonyms: PN1 Host cell: CHO-K1 Gene name: SCN9A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Grow…
Human α4/β2 Nicotinic Acetylcholine Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7023. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch™ HT
BlueScreen HC is based on the fast, accurate GreenScreen HC genotoxicity assay from Gentronix Ltd. BlueScreen HC uses the same human-derived, p53-competent TK6 cells to host a patented reporter system that exploits the proper regulation of the GADD45a gene. However, in place of GFP, BlueScreen HC utilizes a luciferase from the marine copepod Gaussia princeps to generate a luminescent output. The BlueScreen luminescent assa…
For reproducible reversed phase separation: LiChrospher® RP-phases are reliable and versatile traditionally produced spherical silica carrier with reversed phase properties. They are well suited for the chromatography of acidic, neutral and weakly basic compounds, substances found frequently in all analytical fields. A selectivity and performance guarantee makes sure that these parameters remain constant form batch to batch a…
