Action Potential Duration (APD) Testing on hESC-Derived Cardiomyocytes
Evaluate compounds in human stem cell-derived, ventricular-type cardiomyocytes. Effects on action potential parameters are evaluated in single human cardiomyocytes using patch-clamp recording Benefits: Human ion channels expressed in a native cardiac environment Detects AP Prolongation (QT risk) and EADs (Torsade trigger) Stable recordings at physiological temperature with minimal diffusion delays Cost-effective Ra…
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Evaluate compounds in human stem cell-derived, ventricular-type cardiomyocytes. Effects on action potential parameters are evaluated in single human cardiomyocytes using patch-clamp recording
Benefits:
- Human ion channels expressed in a native cardiac environment
- Detects AP Prolongation (QT risk) and EADs (Torsade trigger)
- Stable recordings at physiological temperature with minimal diffusion delays
- Cost-effective
- Rapid turnaround time
Stem-Cell Derived Human Cardiomyocytes (hESC-CMs): Cardiac Current Expression and Utility for Detection of Complex Mechanisms of Drug Action
In this application note from ChanTest, it was investigated whether stem-cell derived human cardiomyocytes (hESC-CMs) could be a valuable tool to assess drug effects on heart rate in the absence of autonomic input. Vardenafil, a phosphodiesterase (PDE) inhibitor used to treat erectile dysfunction, demonstrates systemic side effects, including reduction in systolic and diastolic blood pressure and increased heart rate. The effect of Vardenafil on cardiomyocyte beat rate was investigated using manual patch clamping of single, isolated, hESC-CMs, and cloned HCN4 channels.
