Drug discovery > Drug Manufacturing Products & Reviews

For generating puromycin-resistant feeder layers for the culture and selection of transfected undifferentiated ES and iPS cells

Activin A

Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells

NF-?B Pathway Inhibitor; Stabilizes I?B

Vitamin D receptor activator

Inducer of cardiac differentiation

NF-?B pathway inhibitor; Inhibits NF-?B

Hypoxia inducible factor-1a (HIF1a) inhibitor

Epigenetic modifier; Inhibits histone deacetylase (HDAC) 6

Retinoid pathway activator; Activates retinoic acid receptor (RAR)

Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK

Aryl hydrocarbon receptor (AHR) antagonist

Epigenetic modifier; Inhibits histone methyltransferases SU(VAR)3-9

WNT pathway activator; Inhibits GSK3a and GSK3ß

WNT pathway activator; Inhibits GSK3

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

p53 Inhibitor

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

Activin/NODAL/TGF-ß pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK

MEK/ERK pathway inhibitor; Inhibits B­RAF V600E

Notch pathway inhibitor; Inhibits ?-secretase

Tyrosine kinase inhibitor; Inhibits ABL, SRC, LCK and YES

Notch pathway inhibitor; Inhibits ?-secretase

Inhibits EGFR and VEGFR

Glucocorticoid pathway activator; Activates glucocorticoid receptor