TOYOPEARL AF-rProtein L Affinity Media by Tosoh Bioscience

TOYOPEARL AF-rProtein L  is a high capacity chromatography resin for the capture of antibodies and antibody fragments. This Protein L affinity resin combines the rigid TOYOPEARL polymer matrix with an engineered recombinant Protein L ligand. TOYOPEARL AF-r Protein L-650F exhibits dynamic binding capacities (DBCs) of greater than 38 g/L for Fabs, almost twice the capacity of other commercial Protein L resins.

Protein L has a strong affinity for the variable region of an antibody’s kappa light chain. TOYOPEARL AF-r Protein L-650F is therefore suitable for the purification of a wide range of antibody related molecules which do not bind to Protein A. Examples are antibody fragments (Fabs), domain antibodies (Dabs) and single chain variable fragments (scFv) as well as IgM and IgA. 

TOYOPEARL AF-rProtein L  Features: 

• High protein binding capacity for antibodies and fragments
• Reduced operating costs 
• Increased productivity
• High mechanical and chemical stability