Member since: 2018
Organization: MPI of Biophysics and MPI for Brain Research, Frankfurt am Main, Germany
The rapifleX is vital in identifying new subunits of membrane protein complexes.
Application Area: Identification and characterisation of new subunits of membrane protein complexes
"As part of my research, we realized that we had so many protein structures with unknown densities, we needed a tool to directly sequence them. The rapifleX was not even on the market at this point, so we went to Bruker Daltonic HQ in Bremen and looked at a couple of spectra and from then on, I knew I wanted the rapifleX. I realised that for many of the brain research questions we wanted to address, MALDI imaging would also be an interesting addition to the portfolio."
Member since: 2017
Organization: University Hospital Heidelberg
Worth the price!
Application Area:Screening for new antimicrobials
"Highly recommendable; easy to use - perfect for high-throughput"
Member since: 2013
Organization: Institute of Chemical Technology
Very Good System
"Excellent separations, easy to operate and reliable. Would recommend other analysts to use."
Member since: 2016
Organization: ChungNam University
Good for drug discovery
Application Area:MALDI application
"Bruker MALDI-TOF is easy to use and very useful for mass analysis"
Member since: 2015
Organization: Metrohm USA
MALDI improves my work quality.
Application Area:High thoughput screening
"If you need to increase the sampling rate, you should look at MALDI PharmaPulse. The robotic sample spotting is automatic and smooth. The system works very efficiently and software is easy to use."
Member since: 2016
Organization: Siena College
Bruker Daltonics rules the MALDI world
Application Area:MALDI is a fast and simple tool for screening
"Easy to use and achieve high quality results. Highly recommended."
The rapifleX MALDI PharmaPulse (MPP) accelerates label-free hit finding in drug discovery: rapifleX MPP combines the unambiguousness of mass spectrometry with the required speed to comb through large compound libraries of millions of substances.
The use of mass spectrometry allows the measurement of unmodified substrates in primary screens to avoid false positives or false negatives, making confirmation screens redundant. The system is designed for fully automatic handling of 1536 sample plates to screen more than a million compounds in a week in support of drug discovery.
New standard for ultra-High-Throughput Screening Label-Free ‘Hit’ Identification
By combining the speed of Bruker’s patented Smartbeam™ 3D laser technology with the direct-detection capability of mass spectrometry, the rapifleX MALDI PharmaPulse (MPP) delivers unprecedented screening capability for High-Throughput Screening biochemical assays. It allows you to screen through large and diverse compound libraries at a pace of over a million compounds a week, epitomizing the perfect balance of automation and miniaturization.
The MPP system allows for the measurement of unmodified substrates in primary biochemical screens, and offers several advantages:
The MPP system is specifically designed for fully automatic handling 384, 1536, 3072 and 6144 samples per plate, including automated method development and instant export to LIMS.
The new rapifleX MALDI time-of – flight mass spectrometer is the key enabler for the MALDI PharmaPulse solution. It represents a new era in MALDI mass spectrometry. All performance characteristics of the rapifleX MALDI TOF and TOF/TOF instrument surpasses anything seen before.
The new MALDI PharmaPulse 2.0 software solution completes the rapifleX MALDI PharmaPulse mass spectrometer with a tailored software solution for the provision of HTS campaigns – for non-experts in mass spectrometry. This major step enables scientists working in drug discovery to use label-free mass spectrometry for large screening campaigns of millions of substances.