RapidFire High Throughput MS by Agilent Technologies

The Agilent RapidFire 400 is an integrated autosampler for ultrafast sample cleanup based on automated solid phase extraction (SPE) and introduction to mass spectrometry. Designed for highest-throughput laboratories, the large capacity, temperature-controlled, 1536 well-plate handling robot allows unattended weekend operation with sample injection times as short as 2 seconds. RapidFire 400 builds on successful previous models, combining more than 14 years of high-throughput mass spectrometry innovation.

This system provides reliable high throughput and accurate measurements for the qualification of drug targets like automated ADME in discovery, compound binding assessment, elucidation of metabolic processes, the discovery of novel metabolomics targets, and much more. Fully controlled by a single PC, the RapidFire 400 can be combined with Agilent triple quadrupole, time-of-flight, and quadrupole time-of-flight mass spectrometers, while integrating the Ultivo LC/TQ into the system dramatically reduces the footprint of the autosampler and mass spec combination.

Features:

• Fully automated online sample introduction to Agilent triple quadrupole, time-of-flight, and quadrupole time-of-flight mass spectrometers, using a single control software
• Integrating the Ultivo LC/TQ into the RapidFire 400 footprint saves valuable lab space
• Enables different assays in a single batch based on innovative fluidics using proven Agilent 1260 Infinity II quaternary pumps 
• Eliminating chromatography reduces sample analysis time from minutes to seconds.
• Large sample capacity with storage for over 130,000 samples in 1536-well plates allows longer unattended runs 
• Temperature-controlled sample storage unit stores samples longer without compromising integrity
• Integrated plate handler robotics and barcode reading simplify batch configuration and ensure sample integrity, from loading to analysis
• With analysis times of seconds per sample and SPE cartridges reusable for thousands of samples, solvent use and waste generation are substantially reduced