Exclusively for use with the PhysioMimix™ Single-organ Higher throughput (HT) System, Multi-well Liver-48 (MPS-LC48) consumable plates enable the miniaturization of our well-characterized human liver model that recapitulates the liver’s functionality and microarchitecture. The solution facilitates larger scale, yet cost-effective comparative drug screening. Providing 48 chips within one SBS-standard footprint, the plate easily supports in-plate replicates, controls and 7-point dose responses for data robustness/ reproducibility.
Enabling multi-plate experiments per system, this highly scalable solution brings game-changing throughput for predicting drug safety and efficacy in studies of the human liver. Arranged in a multi-well format, the plate features 48 independent chips each containing a three-dimensional (3D) scaffold. During experiments, scaffolds are continually perfused by oxygen and nutrients, creating the ideal culture conditions for 3D liver microtissue formation from primary human hepatocytes.
This next-generation technology overcomes three adoption limitations, cost/chip, throughput and data confidence so that you can benefit from human-relevant insights earlier than ever before.
Validated applications for Multi-chip Liver-48 plates include:
Liver-48 plates are:
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