MassHunter Software

Robust and reliable screening methods for pesticide analysis in food matrices are a continuous point of challenge with the growing number of matrix samples, varying detection limits, and a continuously expanding list of emerging contaminants. Data-independent acquisition (DIA) methods allow users to simultaneously screen for targets of interest while also evaluating valuable information on unknown compounds. Agilent Technologies demonstrates a DIA methodology for the screening of pesticides in a complex matrix with the Agilent Revident Q-TOF LC/MS. Plus, discover how intelligent reflex automated targeted reinjection has been used for the acquisition of compounds screened as present or questionable.

Tea is one of the most commonly consumed non-alcoholic beverages globally, and assessing pesticide levels in tea is essential for ensuring safe consumption, as required by many multinational regulatory bodies. Agilent Technologies presents a complete GC/TQ workflow solution for the accurate and reliable analysis of 246 volatile and semivolatile pesticides in black tea, with the Agilent 7010D GC/TQ. Discover how this workflow solution allows for quantitation of pesticide residues with LOQs as low as 0.01 ppb, yet also demonstrates calibration accuracy over a dynamic range, spanning up to five orders of magnitude over 0.01 to 1,000 ppb in the complex black tea extract.

Did you know that unexpected instrument downtime and time spent on reruns often result from the first part of your workflow? Download this guide to discover how to ensure confident clinical research results with confident sample preparation.

In this white paper, Agilent Technologies provide support for users of Agilent MassHunter Networked Workstation for TOF and Q-TOF LC/MS systems revision 11.0 or higher whose organizations must comply with these regulations.

Lipidomics is a powerful technique for understanding biological systems and integral in a variety of research areas, including agriculture, clinical research and pharmaceuticals. In this application note, Agilent Technologies highlights some of its available solutions for lipidomics workflows, including GC/MS and LC/MS instrumentation. Download the full brochure to learn more about:

• The challenges of lipid separation
• Lipidomics tools for a variety of applications
• Lipid identification

Mutagenic impurities in APIs and drug products pose a significant risk to health and safety – even in small quantities – and thus are a major concern for drug manufacturers. In this application guide, Agilent Technologies provides an overview of recent regulatory action regarding nitrosamine impurities and outlines a complete workflow solution for the accurate detection and quantification of mutagenic impurities in APIs and drug products.

As a proof-of-principle study, a lipidomics profiling workflow was applied to analyze lipid alterations in the AML K562 cell line in response to a BEZ, MPA, and BaP drug combination. The Agilent lipid analysis workflow was performed with the 6546 LC/Q‑TOF, a mass spectrometer designed to have wide dynamic range while simultaneously providing improved resolution independent of acquisition rate. Key to the workflow is MassHunter Lipid Annotator software, which quickly annotates lipid MS/MS spectra and easily generates a custom library of detected lipids, with deep annotation coverage. These libraries are a critical component of the complete lipid analysis workflow, and support targeted and untargeted lipidomics profiling.

Agilent eMethods are designed to accelerate your startup time by condensing large amounts of technical information and optimized analytical methods into a ready-to-run, downloadable, digital information package. In this application compendium, Agilent presents ready-to-run eMethods using Agilent instruments and solutions in the following areas of cannabis analysis: Potency, pesticide residues and mycotoxins, heavy metals, residual solvents, terpenes, and microbial testing. Click to learn more about Agilent Cannabis Testing Solutions.

Today’s high throughput food laboratories require reliable and timely pesticide residue analysis of varied food samples. To gain the highest productivity of the analytical instrumentation, the JetClean Self-Cleaning Ion Source was successfully applied to pesticide residue analysis, significantly reducing the need for manual source cleaning and increasing the sample throughput of the GC/MS system. Similarly, applying the StreamSelect (SS) configuration to LC/MS systems eliminates the idle time of the MS, and increases the LC/MS system throughput. Both the JetClean and the StreamSelect operations are executed automatically using MassHunter SW.

In this application note, Agilent Technologies describe a method for the quantitative analysis of intact monoclonal antibodies (mAbs) from a biological matrix. The workflow is comprised of an Agilent AssayMAP Bravo platform coupled with an Agilent 6545XT AdvanceBio LC/Q-TOF.

Is your lab audit ready? Ensure you have the tools to help you run a compliant lab. See how a unified software solution for LC/Q-TOF and LC/TOF with technical controls for compliant environments helps you confidently face regulatory audits.

The new systems are designed to tackle challenging targeted analysis applications requiring the highest analytical sensitivity

Watch this webinar to find out how to use the Agilent StreamSelect LC/MS system to increase throughput in your laboratory