HybridSPE®-Phospholipid (HybridSPE®-PL) technology combines the simplicity of protein precipitation with the selectivity of solid phase extraction (SPE) for the targeted removal of phospholipids in biological plasma/ serum. The technology utilizes a zirconia coated particle, and exhibits selective affinity towards phospholipids while remaining non-selective towards a range of basic, acidic and neutral compounds. The phospholipid retention mechanism is based on a selective Lewis acid-base interaction between the proprietary zirconia ions (functionally bonded to the HybridSPE® stationary phase) and the phosphate moiety present in all phospholipids.
Features and benefits: