High Performance Ion Mobility Spectrometry (HPIMS) combines the speed, sensitivity, and robustness of ion mobility with laboratory-grade resolution, specificity and repeatability. It separates molecules by size and shape on a timescale of milliseconds, allowing for rapid compositional analysis and the differentiating between coeluting compounds and isomers.A typical HPIMS analysis takes only 20–30 seconds with excellent specificity and repeatability. Moreover, the straightforward measurement principle of HPIMS (see below) simplifies method development for new compounds, providing value for organizations with many or frequently changing analytes.