ECMatrix by Merck

Manufacturer Merck  |  Available Worldwide
ECMatrix™ laminin substrates for culturing pluripotent stem cells (iPSCs) to promote in vivo–like morphology and simulate a more physiologically relevant environment for better intercellular interactions and better predictive cell models.

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To create better in vitro models of the cellular environment, researchers have historically coated plasticware with distinct ECM proteins and adhesion molecules to facilitate binding by cellular integrin proteins. Human pluripotent stem cells (ES and iPS cells) express the major integrin species α6β1, and therefore can be maintained and expanded efficiently in feeder-free conditions on culture vessels coated with laminin-511 (the binding partner of integrin α6β1). 

ECMatrix™ Laminin Substrates have targeted, proven integrin-binding activity for culturing pluripotent stem cells under feeder-free conditions and offer numerous biological and technical advantages for culturing iPSCs, including: 

  • Animal-free, xeno-free formulation: Lot-to-lot consistency, no prescreening required
  • No plate precoating: Simply add to media while passaging cells
  • Single-cell passaging without ROCKi: Ideal for CRISPR editing or clonal isolation
  • Higher adhesion and growth rates: Achieve target densities sooner
  • Easier to handle: Work at ambient temperature; no chilling cell culture consumables required