Disc1 Knockout Rat by SAGE Labs

Manufacturer SAGE Labs
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.Disc1 Knockout Rat Characteristics: Disc1 is involved in neuronal growth and cortical development The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through th... Read more


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Disc1 Knockout Rat

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This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein.

A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.


Disc1 Knockout Rat Characteristics:

  • Disc1 is involved in neuronal growth and cortical development
  • The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/β-catenin pathway
  • Preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats
  • Background Strain: Sprague-Dawley

Research Applications:

  • Schizophrenia
  • Bipolar disorder
  • Neuronal growth and transport studies