CosMx™ SMI - Spatial Multiomics Single-Cell Imaging Platform by NanoString Technologies, Inc.

Elevate your single-cell research with Spatial Multiomics Single-cell Imaging Solution

CosMx™ SMI is the first high-plex in situ analysis platform to provide spatial multiomics with formalin-fixed paraffin embedded (FFPE) and fresh frozen (FF) tissue samples at cellular and subcellular resolution. CosMx SMI enables rapid quantification and visualization of up to 1,000 RNA and 100 validated protein analytes. With a tunable workflow from high-plex to high-throughput, CosMx enables discovery research by providing high-plex and unbiased whole-slide analysis, as well as translational research with low-plex, high-throughput biology-driven analysis. It enables cell atlasing, tissue phenotyping, cell-cell interactions, cellular processes, and spatial biomarker signature discovery.

CosMx SMI is an integrated sample-to-result spatial biology solution. The CosMx platform utilizes simple sample preparation based on standard ISH/IHC protocols and offers both custom and pre-validated assay panels for straightforward prep and reliable results. The combination of sensitive cyclic in situ hybridization chemistry, an ultra-high-resolution imaging readout instrument, and an interactive cloud-based data analysis and visualization software makes the data simple to collect and interpret.

Features

• High-plex in situ spatial analysis
• Spatial multiomics with any sample type at cellular and subcellular resolution
• Up to 1,000 RNA and 100 validated protein analytes

Applications

• Cell Atlas and Characterization: Define cell types, cell states, tissue microenvironment phenotypes, and gene expression networks within spatial context.
• Cell-cell Interaction: Understand biological process controlled by ligand-receptor interactions.
• Spatial Biomarkers: Quantify change in gene expression based on treatment and identify single-cell subcellular biomarkers with spatial context.