chameleon by SPT Labtech

Manufacturer SPT Labtech  |  Available Worldwide

Next generation sample preparation for cryo-EM based on Spotiton


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chameleon
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chameleon is a blot-free, pico-litre sample vitrification instrument specifically designed to provide a rapid and efficient path to quality frozen grids for cryo-EM

The sample preparation bottleneck...

Recent advances in cryo-EM have led to an explosion of interest in the technique for increasingly challenging structural biology projects. Producing quality frozen grids with vitreous ice of an appropriate thickness and evenly distributed particles remains one of the major bottlenecks in the structure determination process. Currently, highly skilled manual handling needs to be learnt to avoid physical grid damage. Poor traceability of storage locations can also lead to grid losses. Feedback on ice quality requires costly screening on an electron microscope, time better used for more productive data collection. chameleon’s aim is to enable automated, rapid progress to the optimum ice thickness for a range of samples, even those handled by researchers relatively new to cryo-EM.

The chameleon story...

chameleon is a commercial development of the successful Spotiton system, an idea conceived and brought to life by the groups of Bridget Carragher and Clint Potter at New York Structural Biology Centre (NYSBC). Realising the limitations of existing grid preparation practices, they set out to develop a robust and repeatable technique for specimen vitrification based on small volume dispensing using inkjet technology. The 'Spotition' (first published in 2012) as it became known, then underwent a series of iterative improvements in-house and became instrumental in an increasing number of high quality structures and cutting edge research papers on air water interface effects published by the team. chameleon distils out the advantages of Spotition and builds in our proven knowledge of process automation in the field of structural biology.

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chameleon

Manufacturer SPT Labtech  |  Available Worldwide

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