B.I.-LISA IVDr Lipoprotein Subclass Analysis (For research only) by Bruker BioSpin

The Bruker B.I.-LISA lipoprotein panel offers significant benefits versus the current testing modality, e.g. the ultracentrifugation method, which typically takes 1 week per sample. The method is based on the analysis of signals in the ¹H-NMR spectrum which are related to the lipoproteins. Differences in lipoprotein composition, size and density translate into respective signal line shape differences, which can be used to extract information on lipoprotein main- and subclasses.

Key benefits:

• Lower cost than ultracentrifugation
• Much faster turnaround time – minutes versus days
• Completely automated and simple to run (e.g. by an MTA)
• Equal sensitivity and specificity as ultracentrifugation
• Small sample volume (500 microliter) – better patient compliance
• Straightforward sample preparation
• No direct contact between sample and device
• Spectra can be used for multiple types of analysis

Requirements for Lipoprotein Subclass Analysis:

• IVDr platform at 600 MHz
• Use of Bruker SOPs for plasma/serum
• Absolute temperature, solvent suppression and quantification reference sample must be checked regularly (preferably daily)
• Access to Bruker Data Analysis server for fully automated remote analysis (transfer of spectra after measurement to Bruker server via private ftp, back-transfer of result report)