Aura
Aura® is the particle and aggregate detection system that combines Backgrounded Membrane Imaging which images 100% of your sample to give you count, size, and morphological information, with up to 2 channels of Fluorescence Membrane Microscopy. Identify if particles are protein or not with the first FMM channel and determine if your sample contains lipids, hydrophobic entities, or other aggregates of your choice with a second…
Protein (red) vs. other particles (blue)
1µm–5mm particle characterization range
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The Aura® system is the particle analysis platform that gets you to your best formulation faster. It combines Fluorescence Membrane Microscopy (FMM) technology with Backgrounded Imaging (BMI) technology to give you a low volume, high-throughput system that counts, sizes, and IDs protein aggregates. Translation? You can now screen particles as early as lead optimization and pre-formulation testing to gain key drug stability insights earlier, reducing development risk and time to market.
Get the Aura instrument that fits best with your workflow – a brightfield only system that can be updated later, a 1-channel fluorescence system that gives you brightfield and detects ThT labeled protein aggregates, or a 2-channel fluorescence system that adds an additional fluorescence channel to your system. And did we mention that the Aura counts and measures 100% of your sample so sample focus and flow rates won’t ever bias your data? Never worry about what you’re missing with the Aura! Identify, quantitate, and differentiate between proteinaceous and non-proteinaceous materials
- Only requires 5uL of sample volume
- Fluorescence labeling of your choice from standard to custom excitation and emission wavelengths
- Completely automated and fluidic free with minimal optimization
- Large Size Particle Detection Range: 1µm – 5mm 96 sample throughput
- Established USP method
Is your AAV payload impacting stability? Find out with Aura GT
Adeno-associated viruses (AAVs) have transformed gene therapies by enabling the targeted delivery of therapeutic genetic payloads. Aura GT™ from Halo Labs provides a low-volume, high-throughput, and sensitive methodology for comprehensive AAV formulation development. It helps to monitor nucleic acid leakage that can occur under common storage conditions and enables characterization of subvisible particles to improve sample stability.
AAV aggregate quantitation and identification with the Aura system
In this application note from Halo Labs, explore the new Aura™ platform, the first ultra-low-volume, subvisible particle analysis system that quantitatively characterizes the stability of different AAV serotypes with as little as 5 μL. Consider how several AAV serotypes tend to form large, subvisible aggregates that cannot be predicted using other techniques. Furthermore, discover the stability and subvisible particle formation in AAV2, AAV5, and AAV8 under different stress conditions and compare the results to stability predictions made by differential scanning calorimetry.
High-throughput detection of degraded polysorbate in biological formulations with FMM
In this application note, Halo Labs introduces the Aura™ polysorbate degradation assay, a specific and quantitative assay that detects free fatty acid particles (FFAs) formed during polysorbate degradation in 96 samples using anywhere from 5 μL–10 mL of sample.
Waters acquires Halo Labs, expanding biological analysis portfolio
Waters has acquired Halo Labs™ to detect, identify, and count interfering materials (particles) in therapeutic products, such as cell, protein, and gene therapies
7 upcoming webinars to accelerate your science
Discover the latest tools and techniques to expand your research capacity with expert-led presentations on drug development, food allergy, respiratory viruses, and more
Is that a live cell or cell debris? Cell viability meets product purity
Watch this on-demand webinar to learn to how to measure cell viability and foreign particle impurities quickly and accurately, in a single workflow
