Aura PTx
Aura® PTx gets you to your best formulation faster! Backgrounded Imaging (BMI) technology to give you accurate count, size, and morphology information about particles in your sample. Couple that with Fluorescence Membrane Microscopy (FMM), which gives you definitive ID of protein aggregates and an easy way to monitor polysorbate degradation.
Degraded polysorbate particles
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Aura® PTx is the first and only system designed to detect, count, and characterize formulation excipients including polysorbate and related degraded products, and subvisible particles for product quality measurements in protein therapy applications. It also makes it super simple for you to specifically ID protein from non-protein aggregates right out-of-the-box, without having to spend hours sorting through images or needing complex machine learning libraries.
With the 96-well, high-throughput platform, Aura PTx enables comprehensive formulations screening and proper design of experiments with low sample volume to ensure product stability and safety.
Aura PTx combines Backgrounded Membrane Imaging (BMI) with two channels of Fluorescence Membrane Microscopy (FMM) to give you aggregate data without the need to clean between measurements. Get count, size, and morphological information using BMI with full-well imaging and 100% sampling efficiency, or differentiate between cellular, protein, or extrinsic aggregates using FMM to quickly know what’s in your sample.
Identify stable biologic candidates during cell line development with Aura PTx
This application note showcases how Aura PTx enables early characterization of antibody stability during CHO cell line development. By utilizing high-throughput, low-volume subvisible particle analysis, Aura PTx assesses the physical stability of secreted antibodies in unfiltered samples. The method supports informed candidate selection and enhances biologic developability from the start, addressing challenges posed by complex biologic modalities and high titer demands.
Rapidly distinguish protein from non-protein particles in biologic formulations
In this application note, Halo Labs introduces fluorescence membrane microscopy (FMM) exclusively available in the Aura™ system. FMM is presented as a high-throughput, low-volume, subvisible particle identification technology with high sampling efficiency. This technology is positioned as a complementary and orthogonal method to compendial techniques, aligning with regulatory expectations for comprehensive characterization of particulates and aggregates in biopharmaceutical product formulations.
