Member since: 2021
Organization: Bio-Rad Laboratories
Application Area: Cell Free DNA
"This cfDNA material provides consistent peak sizes and closely matches the listed concentration. It works well for various applications and the time to receive the material is very quick. Very happy with this material."
The unique characteristics of native cfDNA compared to fragmented genomic DNA make it the reagent of choice for research and the development of diagnostic methods for cfDNA analysis. The natural “imperfections”, such as nicks, gaps, abasic sites, and covalent modifications present challenges that must be met before developing a diagnostic assay that is effective in a real-life situation
Uses for UltraPure cfDNA:
Validation of liquid biopsy assays including non-invasive fetal testing, circulating tumor DNA variant detection, and organ transplant rejection
Evaluation of in-house purified cfDNA extraction procedures and assay performance
As a negative control for rare variant detection in targeted or amplicon next-generation DNA sequencing assays or droplet digital PCR
Starting material for basic research and assay development
Benefits of UltraPure cfDNA:
Native cfDNA is a real-life control for cfDNA research and development programs and for cfDNA based clinical diagnostic assays
From single-sourced healthy human plasma donors with no known genetic disorders; not cell-line derived
The product consists of nucleosomal monomers, dimers, and trimers; free of high-molecular-weight DNA
Cost-effective relative to user procurement of plasma and purification kits
Meets or exceeds the performance of purified cfDNA extracted by “gold standard” method
Rigorously tested on a per-batch basis for cfDNA purity and efficacy in molecular cloning assays
Shortens research time by eliminating the need for the generation of in-house cfDNA
Lots of UltraPure cfDNA are rigorously tested for physical appearance and PCR amplifiability. A Certificate of Analysis is provided with each purchase.
$200/50 ng, at a concentration of 1 ng/ul. Please inquire for bulk discounts or custom orders. Specific donor gender is available upon request.