ViBE BioAnalyzer
The compact, benchtop ViBE BioAnalyzer is the ideal research tool for assay development or small to medium size studies which require highly-sensitive detection and quantitation of proteins in complex biological mixtures with real-time results. The small foot-print BioAnalyzer can be easily scaled-up to a ViBE Workstation for higher throughput and walk-away operation. The ViBE BioAnalyzer • Ideal for research applications a…
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Review Date: 28 Jul 2022 | BioScale, Inc.
The compact, benchtop ViBE BioAnalyzer is the ideal research tool for assay development or small to medium size studies which require highly-sensitive detection and quantitation of proteins in complex biological mixtures with real-time results. The small foot-print BioAnalyzer can be easily scaled-up to a ViBE Workstation for higher throughput and walk-away operation.
The ViBE BioAnalyzer
• Ideal for research applications and assay development
• Simple manual operation
• Simultaneously process eight samples
• Upgrades to a ViBE Workstation for walk-away operation as sample load increases
• Detects and quantitates proteins in complex biological mixtures
Comparative Analysis of In Vivo and In Vitro Expression of Kinases in the MAPK and PI3K Pathways
The MAPK and PI3K-AKT cascades are signal transduction pathways which heavily influence the regulation of cell proliferation, differentiation, and survival, and as such, are implicated in a wide variety of cancers. In this scientific poster, presented at ELRIG Drug Discovery 2012, the use of non-optical acoustic membrane microparticle (AMMP®) technology to assess and quantify the activation state of several implicated kinases, including EGFR, p38 and AKT, is described. In this poster BioScale demonstrate the feasibility of quantifying biomarker analytes in the complex matrices of cell and tumor lysates using the ViBE Workstation.
Snapshot of MAP Kinase and Related Signal Transduction Pathways from Biopsied Cells Using a Novel Non-Optical Assay Technology
Aberrant activity of the MAP and PI3 kinases is implicated in many forms of cancer. The ability to gather quantifiable information on the activation state of these kinases from limited in-vitro and in-vivo tumor samples would accelerate drug development and ultimately, the treatment of cancer. In this BioScale poster, presented at ELRIG Drug Discovery 2012, non-optical acoustic membrane microparticle (AMMP®) technology was used to quantitate the activity state of multiple kinases including EGFR, MEK, ERK, AKT, p38 and JNK in a single assay plate. Using fewer than 2000 cells per assessment, multiple kinases were measured, in their native states, in a single assay using AMMP technology.
Snapshot of MAP Kinase and Related Signal Transduction Pathways from Biopsied Cells Using a Novel Non-optical Assay Technology
Aberrant activity of the MAP and PI3 kinases is implicated in many forms of cancer. The ability to gather quantifiable information on the activation state of these kinases from limited in-vitro and in-vivo tumor samples would accelerate drug development and ultimately, the treatment of cancer. In this poster, non-optical, AMMP (acoustic membrane microparticle) technology is used to quantitate the activity state of multiple kinases including EGFR, MEK, ERK, AKT, p38 and JNK in a single assay plate.
ViBE Protein Analysis Platform from BioScale
The ViBE® platform from BioScale allows rapid design and configuration of protein assays to achieve highly-sensitive detection and quantitation of proteins in complex biological samples with real-time results. In this video Ken Dick, an Applications Scientist at BioScale, tells SelectScience about ViBE technology and some of its applications, for example in cancer research. As an example Ken discusses how cytokine assays have been developed using the ViBE workstation. Interview filmed by SelectScience at SLAS2013.
Protein Analysis Platform Poster
This poster presentation describes the automated vibe platform, used to identify the optimum yield for protein purification of expressed proteins. Adam Hill, Novartis presents to SelectScience, a summary of the research carried out by Novartis and Bioscale.
