Vena8 Fluoro+ Biochip: microfluidic flow chamber
The Vena8 Fluoro+™ biochip is ideal for studying cell receptor-ligand interaction and is compatible with confocal microscopy. As cells flow through the microcapillary of the Vena8 Fluoro+™ biochip, the cell surface receptors may interact with adhesion molecules or ligands which coat the microcapillary walls. Ideal for use with fluorescence immunostaining, confocal microscopy and for applications such as thrombosis.
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The Vena8 Fluoro+™ biochip is ideal for studying cell receptor-ligand interaction and is compatible with confocal microscopy.
As cells flow through the microcapillary of the Vena8 Fluoro+™ biochip, the cell surface receptors may interact with adhesion molecules or ligands which coat the microcapillary walls. Ideal for use with fluorescence immunostaining, confocal microscopy and for applications such as thrombosis.
Dose Response of Effect of Levocetirizine on Eosinophil Adhesion
In this application note the effect of levocetirizine on human eosinophil adhesion to VCAM-1 and BSA is assessed. Using Cellix’s biochips and Mirus pumping system, eosinophil adhesion to rhVCAM-1 and the dose response effect of levocetirizine on GM-CSF-stimulated eosinophil adhesion to rhVCAM-1 under physiological flow conditions is investigated.
T-Cell Adhesion to ICAM-1
This application note investigates the adhesion of T-cells to ICAM-1 when treated with a range of statins (pravastatin, fluvastatin, mevastatin, lovastatin and simvastatin) under physiological flow. The method presented uses Cellix’s biochips and Mirus pumping system.
Assessing the Adhesion Profile of Platelets on Matrix Proteins
In this application note the adhesion profile of platelets and shear-dependent thrombus formation mechanisms are investigated, on different substrates such as vWF and collagen, using whole blood samples.
Analyzing the Role of Different Adhesion Molecules and Chemokines Involved in Inflammation
This application note analyzes the role of different adhesion molecules and chemokines involved in various stages of inflammation under physiological flow conditions. Using Cellix’s biochips and Mirus pumping system, THP-1, monocyte and PBMC adhesion to VCAM-1; THP-1, monocyte and PBMC rolling on E-selectin; and respective adhesion blockades is investigated. THP-1 adhesion to HUVECs, correlating adhesion assay results with adhesion molecule expression levels on HUVECs from flow cytometry data, is also investigated. This method also investigates THP1 and PBMC adhesion to TNFα stimulated HUVECs and the effect of blocking antibodies (anti-VCAM-1; anti E-selectin; anti ICAM-1 and a combination of all three).
