Thermo Scientific Exactive Plus Orbitrap LC-MS

Isotope ratio mass spectrometry (IRMS) is a powerful tool for determining subtle isotopic variations within a sample and works by breaking down complex molecules in simple gases. This technique can provide unique insights however important intramolecular isotopic information is often lost.

Explore a new, comprehensive approach to IRMS using electrospray ionization (ESI). Thermo Scientific™ Orbitrap™ MS technology gives access to a wide range of isotopic information from a variety of polar compounds in liquid samples. In contrast to classical IRMS methods, Thermo Scientific™ Orbitrap Exploris™ Isotope Solutions enable the calculation of isotope ratios directly from the relative abundances of the compounds isotopologues, measured as intact molecular ions.

Various food contact materials are used throughout the food chain and can give rise to migration (leaching) where chemical substances and metals can transfer to foods. Regulations are complex but a diversity of analytical techniques provide effective tools for monitoring and control. In this white paper, Thermo Fisher Scientific reflects on the current state-of-the-art in terms of types of food contact materials in use and problems which have come to light in terms of migration and safety of food.

From food safety analysis and nutritional testing, to chemical analysis for food quality and food integrity, Thermo Fisher Scientifics's portfolio of application notes demonstrates how its chromatography, trace elemental, and mass spectrometry systems aim to deliver data that is compliant with regulations.

In this application note, discover how Thermo Fisher Scientific has collaborated with the scientific community to develop novel metabolomics solutions that combine Thermo Scientific™ Orbitrap™ LC-MS instruments with data analysis software and libraries.

In this infographic, we explore how a rise in global temperatures due to climate change could mean countries in cool or temperate climates are more at risk for mycotoxin contamination in food and animal feed supply chains. Discover insights into legislation, global prevalence, socioeconomic impacts, and how manufacturers are innovating to help institutions optimize their testing capabilities to comply with international trade regulations and ultimately, ensure food safety.

Residual pesticide testing is an important factor in ensuring global food safety and improved nutrition. In this informative infographic, we explore the international impact of the pesticide problem, socioeconomic risks involved in pesticide use, what can be done, and how scientists can streamline their path to multi-residue testing.

This poster presents a new workflow for high-resolution Thermo Scientific™ Orbitrap™-based mass spectrometers for lipidomics using a model system consisting of a wild-type strain vs. knockout for Co-Q production in yeast.

In this poster, read about a method for analyzing 32 mycotoxins in beer. The multi-mycotoxyin assay is based on very simple sample preparation and ultra high performance liquid chromatography coupled with full spectral Orbitrap™ MS detection.

Lead discovery groups are constantly developing new methodologies to screen large chemical libraries against a specific target. The majority of these methods utilize plate reader devices, ELISA, and other analytical techniques that are amenable to high throughput analysis. Existing analytical methodology used for screening can be less than ideal due to sample prep considerations, limit of detection, and specificity of analyte detection. In this application note read high resolution LCMS can provide a high quality alternative while maintaining a sampling rate that is suitable for HTS requirements.