SamuxMP Auto
The SamuxMP Auto is the automated mass photometer for AAV characterization, autonomously measuring up to 24 samples in approximately 90 minutes. The instrument rapidly measures AAV empty/full ratios, sample purity, and particle aggregation for any AAV serotype – with high precision and reproducibility.
The SamuxMP Auto instrument, showing the mass photometer and
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The SamuxMP Auto offers all the advantages of AAV capsid analysis with mass photometry while adding convenience and reproducibility via automated, highly consistent sample manipulation. It accurately measures empty/full capsid ratios of AAVs, and detects partially filled and overfilled AAVs in heterogeneous samples.
The SamuxMP Auto can autonomously analyze 24 samples in as little as 90 minutes, yet fits on a benchtop. Its integrated software suite allows the user to define measurement protocols, analyzes the 24 measurements on the fly, and makes it easy to plot and export the resulting data in a variety of formats.
The robotics unit can be retrofitted to existing SamuxMP instruments.
Key benefits of the SamuxMP Auto include:
Characterization of AAV samples
Automated measurement
Easy setup
Application of mass photometry in GMP-regulated environments for characterization of AAV samples
In this whitepaper, Refeyn defines how the SamuxMP and SamuxMP Auto can be applied in a GMP-regulated environment and outlines the key features of the SamuxMP software package. The whitepaper addresses challenges in the commercial manufacturing of adeno-associated viruses (AAVs), commonly used vectors for gene delivery. It highlights the limitations of current AAV characterization methods, such as analytical ultracentrifugation (AUC), electron microscopy (EM), or qPCR/ELISA. Mass photometry is introduced as a solution that overcomes bottlenecks, providing reliable data at the single-particle level and aligning with traditional characterization methods.
AAV analytics with mass photometry
Mass photometry is an innovative technology that analyzes biomolecules, including adeno-associated viruses (AAVs), at the single-particle level, in their native state and without the need for labels. In this application note, Refeyn shows that mass photometry is an ideal analytical technology for AAV research, development and manufacturing. In just minutes, a mass photometer can precisely measure the empty/full capsid ratio for AAVs of any serotype. It requires only very small sample volumes and concentrations, and minimal sample preparation.
Comparison of analytical approaches for AAV characterization
Refeyn discusses the pros and cons of the top AAV sample characterization methods
