Products & ReviewLife Sciences
Reconstructed Bone (r-Bone™) 3D Cell Culture Service, Acute Myelogenous Leukemia (AML)
zPREDICTAAvailable: Worldwide
Human, bone marrow 3D culture model enabling accurate testing of therapeutic agents against acute myelogenous leukemia (AML).
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Reconstructed Bone (r-Bone) platform offers 1-to-1 reconstruction of cellular and extracellular compartments of human bone marrow microenvironment. r-Bone preserves the architecture of human bone marrow and enables accurate evaluation of response to treatment.
Unique Advantages:
- Clinically relevant system demonstrating high correlation with clinical outcomes (in a clinical study, 19 out 21 cases of response vs. resistance to treatment were predicted correctly).
- Supports evaluation of efficacy and toxicity in a single assay.
- Suitable for testing of immuno-oncology agents.
- Comprehensive system to ascertain mechanisms of drug resistance.
Features:
- Bone marrow-specific extracellular matrix (ECM) drives native organization of primary multiple myeloma cells ex vivo.
- AML medium supplement enables reconstruction of a disease-specific mileu.
- ong-term survival of primary patient cells (viability is maintained for >30 days as compared to 1-4 days in standard 2D culture or Matrigel).
- Maintains cellular heterogeneity of the primary human bone marrow.
- Suitable for evaluation of single agents and combination treatments.
- Compatible with multiple therapeutic modalities, e.g. small molecules, antibody-drug conjugates (ADC), immuno-oncology agents, including CAR-T cells.
- Compatible with standard readouts, such as FACs, imaging, bioassays, etc.
