PATfix mRNA Platform
Rapid at-line analytical chromatography solution for all stages of mRNA production, purification, and quality assessment.
Place your order directly with the manufacturer.
The PATfix® mRNA Platform is a chromatography-based system designed for rapid and precise analysis of mRNA products throughout the manufacturing process. It enables at-line monitoring of critical quality attributes such as mRNA integrity, capping efficiency, purity, and size with minimal sample preparation—requiring only simple dilution. This platform supports real-time decision-making during process development, scale-up, and quality control.
Equipped with sensitive detectors the PATfix® mRNA Platform provides detailed insights into the molecular characteristics of mRNA drug products. Its flexible software architecture allows secure, remote access to data, facilitating collaboration and data-driven process optimization.
Key Features & Benefits
- Fast requiring only sample dilution
- Monitors capping efficiency, integrity, purity, and size distribution in a single run
- Sensitive detectors suite for high-resolution mRNA characterization
- Enables real-time, at-line monitoring to accelerate process development
- Secure, client-server software supports remote data access and collaboration
Applications
- Monitoring in vitro transcription (IVT) reactions
- Quality control during mRNA manufacturing and purification
- Assessment of capping efficiency and RNA integrity
- Process development and scale-up of mRNA therapeutics
- Support for regulatory submissions with robust analytical data
Higher‑quality mRNA starts with pH‑driven dsRNA removal
Wednesday, March 18 at 16:00 GMT | 17:00 CET | 12:00 EDT | 09:00 PDT
The rapid expansion of mRNA‑based therapeutics has intensified the need for highly reliable impurity‑control strategies. Among these impurities, double‑stranded RNA (dsRNA) poses a significant challenge, as even small amounts can trigger unwanted immune responses and compromise product efficacy.
In this SelectScience® webinar, attendees will explore how pH‑based denaturation and Oligo dT purification enable rapid dsRNA disruption, high mRNA recovery, and improved potency. Join Dr. Rok Sekirnik, head of process development of mRNA/pDNA at Sartorius BIA Separations and Evelin Nett, a PhD researcher specializing in RNA‑based technologies, as they share practical guidance on implementing this methodology in modern mRNA production to enhance mRNA integrity for personalized therapies and vaccines.
Key learning objectives:
- Learn how pH denaturation and Oligo dT purification enable selective dsRNA removal while maintaining high mRNA recovery and integrity.
- Understand how optimized dsRNA‑removal workflows can boost downstream performance, including 5-6x improved cell‑based potency.
- Gain insight how to apply this method using HPLC, FPLC, or centrifugation.
Who should attend?
- Scientists and developers working across upstream, downstream, analytical, and process development in mRNA and gene therapy workflows
- R&D leaders, CDMOs, and specialists advancing therapeutic development and manufacturing strategies
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Webinar details
- Cost: Free to attend
- Location: Online
- Duration: 60 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.
