Optim 2: High Throughput Protein Stability Instrument
Optim is an innovative analytical instrument designed to probe multiple protein stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules. Compact and robust, using a light scattering and fluorescence technology in a configuration never seen before and controlled by an all-new easy-to-use intuitive software package, the Optim 2 has been designed to reduce the time and cost of…
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Optim is an innovative analytical instrument designed to probe multiple protein stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules.
Compact and robust, using a light scattering and fluorescence technology in a configuration never seen before and controlled by an all-new easy-to-use intuitive software package, the Optim 2 has been designed to reduce the time and cost of therapeutic protein preformulation studies, protein stability testing and formulation development.
Optim 2 will simultaneously measure a range of protein stability indicating parameters including unfolding transition temperature (Tm), aggregation onset temperature (Tagg) and rates of aggregation, giving you greater insight into identifying the candidate molecules or formulations with the most favourable properties much earlier in the development process. Earlier analysis eliminates the cost associated with the unnecessary development of candidates or formulations that do not have the potential to proceed and dramatically reduces the chance of late-stage failure.
Optim 2 Features:
- Speed of analysis - Capability to analyse up to 48 temperature controlled samples simultaneously. 144 samples measured in a high resolution thermal ramp per day
- Low sample availiability - Best in class sample volumes, only 9 microlitres per sample
- Orthogonal stability indicating measurements - Simultaneous fluorescence and light scattering analysis for label free probing of both protein unfolding and aggregation. Analysis of the effects of temperature, time and chemical environment on your biomolecule
Applications:
- Lead candidate selection and optimisation
- Preformulation studies
- Candidate formulation
- Stability studies
Optim Case Study
A unique high-throughput, micro-volume protein analysis and characterization system. Researchers at DSM have invested in an Optim 1000 system in order to characterize enzymes and predict their stability for use in the production of foods and pharmaceuticals.
The Use of Temperature Dependent Intrinsic Fluorescence for the Analysis of the In-Process Stability of a Protein
This poster presents a study using in-process samples of a Monoclonal Antibody from a conventional purification development. Each stage of the process is assessed using a DOE approach to map the design space and find the optimal processing conditions. In parallel, a stability assessment of the antibody at each stage is carried out using the Optim® 1000 to determine the overall manufacturability of the product.
Optim® Case Study: A Unique High Throughput, Micro-Volume Protein Analysis and Characterization System
Read this case study to learn how pharmaceutical developers at Synthon, a global specialist in the development and manufacture of generic and biopharmaceutical medicines, have chosen an Optim 1000 high throughput, micro-volume protein analysis system from Avacta for preliminary formulation studies.
