NexION® 2000 ICP Mass Spectrometer

PerkinElmer addresses the growing need for accurate multi‑element analysis in plant‑based food products, where both major nutrients and trace contaminants must be quantified reliably. Discover how you can streamline your ICP‑MS (inductively coupled plasma mass spectrometry) workflow using PerkinElmer’s NexION® 2200 ICP-MS and MPS 320™ microwave digestion system. This method demonstrates excellent sensitivity, accuracy, and stability, offering a robust solution for routine food testing, formulation decisions, nutritional labeling, and heavy‑metal monitoring.

For many years, inductively coupled plasma mass spectrometry (ICP-MS) has been the technique of choice for trace element analysis in biological fluids. Researchers have found correlations between essential element levels and diseases, metabolic disorders, environmental exposures, and nutritional status. This application note demonstrates the advantages of the NexION 2000 ICP-MS for trace elemental analysis in blood and serum, and explores the ability to simplify sample preparation.

Drinking water must be “wholesome”, as defined in law by standards for a wide range of substances, organisms and properties of water. The standards are set to be protective of public health, and are driven by a number of factors, including safety and health concerns. This application note demonstrates the ability of PerkinElmer’s NexION® 2000 ICP Mass Spectrometer (ICP-MS) to analyze natural and drinking waters in accordance with EPA Method 200.8.

Milk is a widely consumed food product for both adults and children, while formula milk may constitute a major nutrient source for infants. Because of its nutritional importance and widespread consumption, regulations in many countries necessitate that the quality of the milk is routinely monitored. The following application note showcases the NexION 2000 ICP-MS for the analysis of milk samples for major and trace elements, demonstrating the benefits of the All Matrix Solution (AMS) system

​With the continued growth in global population and industry, liquid and solid wastes from a variety of sources are being generated and making their way into the environment. The following application note demonstrates how PerkinElmer’s NexION® 2000 ICP Mass Spectrometer (ICP-MS) can be used as a simple collision cell instrument to meet the needs of analytical laboratories involved in the analysis of waters and soils.

The uptake of metals into individual cells is of interest to both environmental and human health studies, whether the metal is dissolved or exists as nanoparticles (NPs). Currently, cellular metal content is studied by removing the cells from their culture media (either by centrifugation or filtration), washing with fresh media solution, and then acid-digesting them for analysis by ICP-MS.

Cisplatin is one of the most widely used of platinum-based cancer chemotherapy drugs. Its effectiveness is due to its ability to bind to the DNA, resulting in DNA-platinum (Pt) adducts, which in cancer cells block DNA replication and result in cell death. A new, emerging technique has been developed that allows for the quantitation of metal at the level of a single cell: Single Cell ICP-MS (SC-ICP-MS). This application note describes how SC-ICP-MS is used to explore cellular uptake of cisplatin at the single cell level and proves the robustness of the method.

Multi-Quadrupole ICP-MS, FT-IR, and automation innovations provide testing and research performance, flexibility, and ease of use

Watch this on-demand webinar to find out more about how to adopt and streamline ICP-MS based solution approaches in elemental impurity testing

Learn how studying metal uptake at a single cell level is helping to assess cancer drug performance and create more effective therapies