CIMmultus Swiper
CIMmultus Swiper is an innovative solution for efficient RNA purification across diverse types like mRNA, saRNA, circular RNA, and non-coding RNAs
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The CIMmultus® Swiper is a chromatography column crafted for superior RNA purification, particularly excelling in the purification of non-polyadenylated RNA where traditional methods often fall short. Harnessing multimodal weak anion exchanging properties, it provides remarkable selectivity between RNA, DNA, and proteins, making it ideal for complex samples. Operating efficiently within an acidic to neutral pH range, it achieves high recovery rates above 80%, contributing to reduced therapeutic costs. Designed to operate under gentle conditions, it maintains RNA integrity through mild loading and neutral pH elution, ensuring optimal performance for sensitive RNA constructs. Its scalable, reusable design facilitates cost-effective purification from volumes ranging from 1 mL to 8 L, accommodating needs from research and development to commercial production.
Key features:
→ Broad compatibility with various RNA types, optimal for purifying non-polyadenylated RNA.
→ Ensures high recovery rates, typically above 80%, aiding in cost reduction.
→ Conducts purification under mild conditions and neutral pH elution to preserve RNA integrity.
→ Scalable and reusable design supports purification from 1 mL to 8 L efficiently.
Relevant applications:
→ Efficient purification across diverse RNA types, including mRNA, saRNA, circular RNA, and non-coding RNAs.
→ Suitable for nucleic acid purification at both R&D and commercial scales.
Higher‑quality mRNA starts with pH‑driven dsRNA removal
Wednesday, March 18 at 16:00 GMT | 17:00 CET | 12:00 EDT | 09:00 PDT
The rapid expansion of mRNA‑based therapeutics has intensified the need for highly reliable impurity‑control strategies. Among these impurities, double‑stranded RNA (dsRNA) poses a significant challenge, as even small amounts can trigger unwanted immune responses and compromise product efficacy.
In this SelectScience® webinar, attendees will explore how pH‑based denaturation and Oligo dT purification enable rapid dsRNA disruption, high mRNA recovery, and improved potency. Join Dr. Rok Sekirnik, head of process development of mRNA/pDNA at Sartorius BIA Separations and Evelin Nett, a PhD researcher specializing in RNA‑based technologies, as they share practical guidance on implementing this methodology in modern mRNA production to enhance mRNA integrity for personalized therapies and vaccines.
Key learning objectives:
- Learn how pH denaturation and Oligo dT purification enable selective dsRNA removal while maintaining high mRNA recovery and integrity.
- Understand how optimized dsRNA‑removal workflows can boost downstream performance, including 5-6x improved cell‑based potency.
- Gain insight how to apply this method using HPLC, FPLC, or centrifugation.
Who should attend?
- Scientists and developers working across upstream, downstream, analytical, and process development in mRNA and gene therapy workflows
- R&D leaders, CDMOs, and specialists advancing therapeutic development and manufacturing strategies
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Webinar details
- Cost: Free to attend
- Location: Online
- Duration: 60 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.
