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Shimadzu introduces iMScope™ QT Imaging Mass Microscope for high-level mass spectrometry imaging analysis

Shimadzu Corporation
16 Jun 2022
Ellie Abbott
Biochemist

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Shimadzu Scientific Instruments introduces the iMScope QT imaging mass microscope designed for use with Shimadzu’s Q-TOF LCMS-9030 mass spectrometer for fast acquisition of high-mass, high-resolution images at the optical and molecular level. When paired with the Q-TOF LCMS-9030, the iMScope QT provides a complete, high-end analytical solution combining precise tools and data processing that is unrivalled in the marketplace.

The iMScope QT consists of an optical microscope, an AP-MALDI ion source, and the Q-TOF LCMS-9030. It allows for the identification of molecules in a tissue region area immediately after microscopy. Detailed portions or entire MS images can be visualized quickly and efficiently. Integration with the LCMS-9030 enables obtaining distribution information and quantitative data for comprehensive analysis.

The system overlays observations from the optical iMScope QT imaging mass microscope with mass spectrometry images to provide thorough analysis all in one solution. The combined optical microscope and MS system accelerates analysis and improves the reliability of results at each step—pretreatment, data acquisition, and data analysis.

In addition to performance, the iMScope QT offers unmatched versatility as it can be easily attached or detached from the LCMS Q-TOF to switch between mass spectrometry imaging and high-sensitivity LC-MS analysis. Simply detach the iMScope QT from the Q-TOF LCMS, switch from an AP MALDI interface to ESI, and connect an HPLC.

Analysts can build a comprehensive imaging solution with Shimadzu’s powerful, easy-to-use pretreatment solutions and data analysis software. The iMLayer AERO automatic sprayer and iMLayer matrix vapor deposition system enable more reliable pretreatment that leads to higher sensitivity and higher spatial resolution. IMAGEREVEAL software is a powerful solution for seamless analysis of large datasets because it enables multiple analysis modes and data processing in as few as three steps. The combination of the iMScope QT with these tools makes Shimadzu the only company providing solutions for all three phases of mass spectrometry imaging.

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iMScope QT

Shimadzu Corporation

The iMScope QT inherits the concept of a mass spectrometer equipped with an optical microscope from the iMScope series, the iMScope QT is also Shimadzu's fllagship model for MS imaging with a Q-TOF MS. The iMScope QT boasts not only fusion with morphology studies but also excellent speed, sensitivity, and spatial resolution, clearing the way to next-generation mass spectrometry imaging.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ImagingImaging techniques are essential for obtaining visual representations of samples to understand structures, processes, and function in biological, chemical, and physical research. These tools range from traditional light microscopy to advanced imaging modalities like MRI and electron microscopy, providing researchers with valuable data for diagnostics, drug discovery, and material analysis. Explore imaging solutions in our peer-reviewed product directory to compare products, check reviews, and get pricing directly from manufacturers.MicroscopyMicroscopy is a technique used to observe small objects in detail, from cells to materials, using light or electron microscopes. It enables researchers to examine structures with high resolution, aiding in fields such as biology, medicine, and materials science. With advanced microscopy techniques, scientists can gain insights into cellular processes, tissue structures, and material properties. Explore the best microscopy solutions in our peer-reviewed product directory, compare products, read customer reviews, and get pricing directly from manufacturers.ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis.

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Shimadzu introduces iMScope™ QT Imaging Mass Microscope for high-level mass spectrometry imaging analysis