Special Feature: Innovations in cell and gene therapy development and the technologies that have advanced the field

This special feature highlights interviews and resources about the latest advances in cell and gene therapy and the technologies behind them

10 Oct 2023

Microbiome Special Feature

Cell and gene therapy is an exciting area of biopharma that offers the potential to treat, prevent, or cure diseases for which there is currently no other therapeutic option – for example, rare diseases and cancers. As the field develops, new methods and technologies for ensuring cell and gene therapy safety and efficacy are essential. 

Cell therapies involve altering cells outside of the body so that they can restore normal function when introduced back into the patient. Gene therapy, on the other hand, involves changing or restoring the genetic function of a cell by introducing new genetic material, typically delivered by a vector that targets specific patient cells in vivo. By addressing the underlying genetic causes of disease, cell and gene therapies provide targeted treatment. 

The analysis of both cell and gene therapy products and their effect requires the application of many advanced techniques and technologies – from plasmid analysis for gene therapy vectors, to the immunoassays used in bioprocess analytics, and monitoring immune response to gene therapies. Together these studies will help to optimize the development of new life-changing treatments as well as the methods that will help bring cell and gene therapy products to market faster. 

In this SelectScience® special feature, explore some of the latest technologies and methods used to advance cell and gene therapy development.  

1. Services to support your gene and cell therapy development

From target selection and validation, to CRISPR editing and payload optimization, transgene delivery optimization, and solutions for preclinical, and clinical stages, discover how GenScript’s products and services can support development and manufacturing. 

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2. The importance of investigating complement system in gene therapy 

Dr. Anna Majowicz, Preclinical Immunology Lead, Spark Therapeutics, discusses work to identify and characterize immune responses that might occur after the infusion of AAV-based gene therapies and how this will help to develop safe and efficacious therapies.  

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3. Plasmid isoform analysis in 5 minutes

Discover a simple and rapid method for discriminating between covalently closed circular, open circular, and linear forms of plasmid DNA using anion exchange chromatography on a TSKgel® DNA-NPR column from Tosoh Bioscience. 

Download method

4. Increase productivity in cell and gene therapy bioprocessing 

In this whitepaper, Gyros Protein Technologies investigates the analytical requirements of viral vector immunoassays used in cell and gene therapy in detail, and explores how automated and reliable immunoassays can lead to increased productivity

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5. Assessment of integrity and purity of mRNAs from lipid nanoparticles

 To ensure the quality of LNP-based drugs, comprehensive characterization of these sophisticated molecules is paramount. Explore how to achieve high-quality, robust assessment of the integrity and size of mRNA molecules encapsulated in LNPs with this technical note from SCIEX. 

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6. Overcome development and manufacturing challenges of T cell-based therapies 

In this comprehensive eBook, learn more about the biological and manufacturing challenges for T cell therapies, and discover products, services, and a resource from Bio-Techne that can help overcome these obstacles at each process stage. 

Download eBook

Graphic of DNA to represent the methods used in cell and gene therapy
Cell and gene therapy is an exciting area of biopharma that offers the potential to treat, prevent, or cure diseases with underlying genetic causes. © Sergey Nivens @123rf.com

Further resources to enhance cell and gene therapy discovery and development

  • Bioprocessing : Learn how you can harness the latest bioprocessing technology in cell and gene therapy in this interview with Lina Tao, Vice president, Eppendorf SE Bioprocess Unit, and learn how 3D-stirred bioreactors could become the industry’s new gold standard. Read article >> 
  • Quality control: In this guest editorial, BioPhorum explores potential improvements to ensure quality in cell, gene and RNA therapy development and to overcome the issues associated with guidance and standardization that are still being developed. Read article >>
  • Cancer treatment: In this Q&A, Jai Balkissoon, M.D., FACS, Head of Cell and Gene Therapy, Thermo Fisher Scientific, and Dr. Evan Zynda, Sr. Staff Scientist, Thermo Fisher Scientific, highlight the key trends and challenges in cell and gene therapy. Plus, they explore the latest advancements in cell therapy for cancer treatment. Read article >>
  • Virtual summit: Access the SelectScience Biopharma Summit on demand to watch presentations on topics including the standardization of traceability of personalized cell and gene therapies, innovation and collaboration in regulatory science, and more. Watch on demand >>
  • AI & mass spec: Dr. Mimi Roy, a leading scientist working at the cutting edge of developing gene therapies for rare diseases, discusses the basics of gene therapies and viral vectors and why AI and mass spectrometry are advancing the field in this SelectScience Accelerating Science podcast. Listen to podcast >>

Read reviews on all the products advancing cell and gene therapy research

Find out what researchers around the world are saying about the products they use, including Andreas Mitsch, of Leibniz-Institut für Immuntherapie, who shared his thoughts on the NucleoCounter® NC-200™ automated cell counter from ChemoMetec and its use in the manufacture and quality control of cell therapy products. 

"We replaced our manual cell counting procedure with the NC-200 for in-process and final product controls of ATMP manufacture. High increase in reproducibility and reduction of analysis time greatly supported optimization of cell therapy manufacturing process." 

Photo of the NucleoCounter® NC-200™ automated cell counter from ChemoMetec
The NucleoCounter® NC-200 automated cell counter from ChemoMetec 

Ease of use: 5/5

After sales service: 5/5

Value for money: 5/5

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