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Agilent announces new ion mobility LC/Q-TOF and enhanced solutions for biotherapeutics at ASMS 2021

Agilent Technologies

New solutions are designed to accelerate the development of new protein-based therapeutics

5 Nov 2021
Blake Forman
Content Creator

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Agilent Technologies Inc. has announced the new Agilent 6560C Ion Mobility LC/Q-TOF, enhancements to the VWorks automation software suite, and new AssayMAP large capacity cartridges.

As the market for protein biotherapeutics expands, pressure increases to improve the efficiency and efficacy of the development process. Researchers need more powerful, insightful instrumentation and software, as well as automation. There is also more focus on regulatory compliance, requiring organizations to maintain data integrity. These new Agilent products address specific stages of the development workflow, from sample preparation to secure protocols, and software to complex protein structural analysis.

“By expanding our instrument portfolio, software solutions, and sample preparation capabilities, Agilent delivers significant value for the development of biotherapeutics in this fast-growing market, allowing for deeper characterization of proteins,” said Sudharshana Seshadri, vice president and general manager of Agilent’s Mass Spectrometry Division. “These introductions reinforce Agilent’s commitment to supporting and enhancing the speed of discovery and development of novel protein biotherapeutics to improve the quality of life.”

Brandon Ruotolo, professor of chemistry at the University of Michigan, agrees and is already seeing benefits from the new Collision Induced Unfolding (CIU) capability. “The CIU technology has been transformative for my research,” said Ruotolo. He added, “It has greatly enhanced our ability to develop rapid, structurally sensitive assays targeting systems ranging from large protein assemblies to biotherapeutic antibodies. I can’t wait to see what the future holds.”

The new 6560C Ion Mobility Q-TOF adds new capabilities that enhance flexibility and performance over its predecessors for more precise measurements of large protein complexes such as biotherapeutic antibodies and large protein assemblies. Protein folding and structural analysis are now possible by CIU, and HRdm 2.0 postprocessing generates IM resolution of up to 250.

New features of the VWorks 14.1 automation software suite enhance support for 21 CFR Part 11 and Annex 11 with e-signatures and secure protocols for AssayMAP. VWorks 14.1 offers seamless adoption of automation and the Bravo platform into regulated environments to improve sample throughput, enhance reproducibility and reduce errors.

The AssayMAP large capacity cartridges extend the portfolio of available chemistries with the introduction of Protein A affinity purification cartridges and reversed-phase cartridges for antibody enrichment and peptide cleanup, respectively. These products enable automated sample preparation upstream of multiple critical quality analyses across the biotherapeutic development process.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.

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