Oncogenic mutations of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, have been identified in a number of carcinomas. More recently, overexpression of mutated ALK has been linked to neuroblastoma cancer cells and is associated with poor prognosis in young patients. While current therapies target intracellular signaling cascades, ALK mutant variants demonstrate kinase inhibitor resistance, and therefore new mechanisms to target these cancer cells are crucial for better treatment.
Join this webinar to discover how researchers at LifeArc are investigating a novel approach whereby cytotoxic agents are conjugated to ALK-specific antibodies as a mechanism of directly targeting ALK-expressing neuroblastoma cells.
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