Expert Insight: Intact mass analysis of modified oligonucleotides and impurities using the BioAccord LC-MS System

Join us on Wednesday, December 2, to learn how the BioAccord LC-MS System delivers robust UPLC separations performance and accurate mass data for a diverse range of modified oligonucleotides

20 Nov 2020



 Dr. Catalin Doneanu, Principal Chemist at Waters

As the pipeline for oligonucleotide-based therapeutics continues to grow, with >300 currently in clinical trials, along with an increased demand for GMP/GLP-validated oligonucleotide reagents (including primers, probes, gRNA) for clinical DNA testing/sequencing, the need for robust, compliance-ready LC-MS analysis of oligonucleotides has never been greater.

Waters has designed the BioAccord LC-MS System to deliver robust, reproducible separations and accurate mass performance in a compact, easy-to-use format; one that facilitates deployment across regulated development, manufacturing and QC labs and supports a range of routine biopharmaceutical analyses, including oligonucleotide analysis. In this webinar, hear from Dr. Catalin Doneanu about recent work demonstrating the utility of the BioAccord LC-MS system and find out how this system has helped users analyze and monitor a diverse range of modified oligonucleotides and known impurities using the compliance-ready intact mass analysis workflow.

Watch this webinar to:

  • Learn how the BioAccord LC-MS system delivers robust UPLC separations performance and accurate mass data for a diverse range of modified oligonucleotides
  • Learn how mass spectral deconvolution algorithms and isotopic models can impact mass accuracy, particularly for phosphorothioated oligonucleotides, and how the BioAccord makes it easy to select the right combination.
  • Discover how compliance-ready data acquisition, processing and reporting take the worry out of meeting data integrity and regulatory requirements.

Who should attend?
This webinar will provide insights for:

  • Lab directors, managers and analytical scientists engaged in oligotherapeutic development, manufacturing, and QC
  • Analytical scientists supporting the development and manufacturing of oligonucleotide primers and probes for PCR-based diagnostics, including targeted next-generation sequencing
  • Incoming QC managers who verify the ID, purity, and quality of incoming oligonucleotides from third-party manufacturers

Certificate of attendance

All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

This webinar will run as two sessions, the first session will run on Wednesday, December 2, at:

  • 16:00 GMT
  • 17:00 CET
  • 08:00 PST
  • 11:00 EST

The second session will run on Thursday, December 3, at:

  • 10:30 IST
  • 13:00 CST
  • 14:00 JST

Register for this webinar here>>

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