Traditional ligand binding assays (LBA) as a method for quantification of biotherapeutics in biologics matrices are being coupled with liquid chromatography tandem mass spectrometry (LC–MS/MS) to obtain more specificity and increase linear dynamic range (LDR), thus creating hybrid LBA/LC–MS/MS methods. This hybrid workflow is more sensitive and consistent than traditional methods, which is critical in efficacy and safety testing.
With the focus on sample preparation and mass spectrometry, LC is often overlooked. However, chromatographic optimization for hybrid LBA/LC-MS/MS methods step can ensure a robust analysis. In this webinar, Brian Rivera, Product Manager of Bioseparations and Specialty LC at Phenomenex, will discuss the importance of magnetic bead and chromatographic media selection for hybrid LBA/LC–MS/MS workflows.
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This webinar will run on Friday, October 9, at:
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