Liquid chromatography (LC) is a fundamental technique used within the analytical laboratory. Bringing your lab up to speed with the latest liquid chromatography solutions can be a challenge. Users must consider their application, sample chemistry, throughput, accuracy, and sensitivity in order to optimize their analysis.
In this SelectScience webinar series, now available on demand, liquid chromatography experts provide insights on LC solutions for those in the analytical lab including advice on labs working with challenging metal-sensitive analytes. Plus, gain insight into how to ensure a seamless transition of methods to newer LC assets.
Think you’d benefit, but missed the live event? Register now to watch the webinar series at a time that suits you or read on for highlights from the individual sessions.
In the first session of the webinar series, Dr. Bruce Register discussed how BriOri BioTech has developed a next-generation topical osteoarthritis drug with the potential to neutralize inflammatory pain and render opioid use obsolete for osteoarthritis of the knee. Dr. Register explained how using the ACQUITY Premier System and ACQUITY Premier Columns from Waters Corporation helped his team overcome challenges with carryover due to the metal-sensitive nature of the analyte of interest.
Analytical Quality by Design (AQbD) is a systematic approach to method development that incorporates risk assessment and design of experiments (DoE) to investigate interaction effects on method performance. In this session, the challenges involved in the Ultra High Performance Liquid Chromatography (UHPLC) analysis of metal chelating compounds were discussed as well as solutions developed using the Analytical Quality by Design (AQbD) approach to mitigate the undesired interactions between metal chelating compounds and metal surfaces.
Validated analytical methods are often transferred across laboratories and to partners such as contract research organizations (CROs) which may be equipped with LC systems from a variety of vendors. The transfer of validated methods is also necessary when replacing aging LC systems with newer technology. The reproducibility of the results generated from transferred methods is vital to ensuring quality control and compliance with regulatory guidelines. In the final session of the webinar series, industry experts explored how to ensure the transition to newer LC technology is seamless, including the transfer of validated methods, and results with minimal instrument downtime.