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Waters Corporation Unveil New Technology Solutions for Increasing Clinical Laboratory Efficiencies

Waters
25 Jul 2011
bridget bridget
Laboratory Director

Product news

Waters Corporation today unveiled new technology solutions for increasing clinical laboratory efficiencies including the first CE Marked LC/MS/MS integrated solution for the quantification of everolimus (Certican®).

Being displayed in Waters booth #3136 are these exciting new products.

•MassTrak™ Online Solid Phase Extraction Analyzer providing automated sample clean-up, concentration, and extraction complemented by Waters® ACQUITY® TQD tandem quadrupole mass spectrometer for high-sensitivity quantitative analysis.

•MassTrak Immunosuppressants XE Kit – CE marked in accordance with the IVD Directive 98/79/EC for the quantification of tacrolimus (FK506;Prograf®) in liver and kidney transplant patients and everolimus (Certican®)
Educational Workshops

This year, Waters is sponsoring two scientific workshops which are designed to further the education of laboratory technicians, scientists, and chemists responsible for developing, implementing, and maintaining robust clinical assays. Each workshop features presentations from leading practitioners in the field of clinical chemistry.

•Good Method Development and Validation Practices for Liquid Chromatography – Mass Spectrometry (LC-MS)
Tuesday, July 26, 6 – 7:30 p.m., Hyatt Regency Atlanta, Regency Ballroom VII.

•Implementing LC/MS/MS in the Clinical Laboratory, Wednesday, July 27, 6 – 7:30 p.m., Hyatt Regency Atlanta, Centennial Ballroom III.

Scientific Posters

Waters scientists and customers will be presenting several scientific posters at AACC including:

•Everolimus Measurement: Evaluating the Waters MassTrak Immunosuppressant XE Kit for use with LC/MS/MS
•Development of a Rapid Quantitative/Semi-Quantitative LC/MS/MS Method to Monitor Opioids and Glucuronide Metabolites
•Measurement of 25-Hydroxyvitamin D3 and C3-epi-25-Hydroxyvitamin D3 Using UPLC/MS/MS in Pediatric and Adult Populations
•Evaluation of LC/MS/MS Scrambling Ratios for Deuterium-Labeled Vitamin D Metabolites, Steroids and Other Compounds of Clinical Significance
•Development of an LC/MS/MS Method for 1,25 Dihydroxy Vitamin D for Use in the Clinical Laboratory

Links

WatersCompany website

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. 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Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. 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