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Unlocking the Potential of Cell Delivery Agents

29 Sept 2013
Kerry Parker
CEO

Product news

Link Technologies Ltd, an ISO 9001:2008 certified specialist oligonucleotide reagent manufacturer, will be presenting a poster at the upcoming 9th Annual Meeting of the Oligonucleotide Therapeutic Society (OTS), 6-8 October, Naples, Italy. The poster entitled 'New Potential Oligonucleotide Delivery Reagents', details how Link Technologies' novel modifiers can enable the enhanced delivery of oligos for therapeutic effect.

Inspired by their existing collection of lipophilic modifiers, which have been proven to enhance cell penetration, Link Technologies has developed this new collection of modified phosphoramidites, and are inviting collaborative partners to help discover their full application potential. At OTS, Dr Catherine McKeen, Technical Manager at Link Technologies, will be on-hand throughout the poster presentation sessions to provide further information and answer any questions.

For more information on Link Technologies and our enabling lipophilic modifiers for cell delivery, please attend our poster presentation at OTS or request a free copy of our 2013/14 Product Guide. Providing comprehensive information for scientists working with modified oligos, including validated protocols and supporting application notes, the new product guide is an ideal go-to resource for oligonucleotide chemistry.

Alternatively, please visit the website at www.linktech.co.uk or follow us on Twitter: @linktechdna.

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Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Drug DosageDosage is the size or frequency of the administration of a drug. Determination of the dosage of a drug is critical in pharmaceutical development to ensure the optimum balance between efficacy and toxicity.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.

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