Trending in biopharma: From developing vaccines for pandemics, to overcoming omic workflow bottlenecks
Watch exclusive interviews with industry experts on the key to vaccine development success, the role of biomaterials in creating drug models, and more
31 Mar 2022
Blake Forman
Content Creator
Editorial article
Here, we’ve pulled together a playlist of top interviews from The Scientists' Channel, our independent video platform for scientists and clinical experts around the world to share their work. Take a look at the videos below to learn more about the advantages of T-cell vaccines and how to overcome bottlenecks in omics workflows. Plus, discover the role of bioconjugation and protein services in conjugate vaccine development.
Developing vaccines for pandemics: Why equity and education are key
Dr. Margaret Liu, CEO of PAX Therapeutics, explains how her early research on vaccine development became critical to the COVID-19 pandemic. Dr. Liu also reveals the advantages of T-cell vaccines, explores some of the key learnings from the pandemic, and highlights the critical role of education in overcoming future health crises.
How to overcome omic workflow bottlenecks
Dr. John Wilson, Founder and CEO of ProtiFi, discusses the importance of reproducibility in omic workflows and explains how ProtiFi has been able to help simplify processes from sample collection and preparation, to process control, chromatography, and data analysis in the early detection of disease.
The magic behind conjugate vaccine development
Dr. Andrew Lees, CEO and Scientific Director of Fina Biosolutions, explains how Fina Biosolutions has grown to offer a variety of bioconjugation and protein services in its dedication to the provision of affordable conjugate vaccines.
Advances in biomaterial development
Dr. Mohammad Albanna, CEO and Founder of Humabiologics, discusses his team’s work providing biomaterials for applications such as bioprinting, tissue engineering, and the creation of cancer models for drug screening.
Rare disease: How miniaturized immunoassays are advancing therapeutic development
Mark Dysinger, Associate Director, Bioanalytical Development, Alexion Pharmaceuticals, describes how miniaturized immunoassays benefit the accurate analysis of drug-target engagement.
Discover more biopharma content on The Scientists' Channel including interviews with speakers who took part in the SelectScience Virtual Biopharmaceutical Summit 2021:
- Combating cancer: The incubation technology accelerating CAR-T cell therapy development: Dr. Gerhard Bauer, Professor of Hematology and Oncology and Director of the Good Manufacturing Practice (GMP) laboratory at the UC Davis Institute, highlights his current work on the production of CAR-T cells, powerful therapies that use a patient's own immune cells to treat cancer. Watch video >>
- Developing a whole molecule approach for biopharmaceutical analysis: Dr. John Kellie, Associate Fellow, Bioanalysis, Immunogenicity and Biomarkers, GSK, describes a technique for the quantitation of whole molecule biopharmaceutical candidates using high-resolution mass spectrometry. Watch video >>
Visit The Scientists' Channel to watch new videos and stay up to date on the latest research>>
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Compound AnalysisCompound analysis is used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds have the desired effect, such as interaction with a target protein, during high throughput screening.Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.ImmunoassayImmunoassays are laboratory tests that utilize antibody-antigen interactions to detect specific substances. They are widely used in diagnostics for detecting diseases, drug testing, and environmental monitoring. These assays offer rapid, sensitive, and precise detection of biomarkers, making them invaluable in clinical and research labs. Browse our peer-reviewed product directory to compare immunoassay systems, read user reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers.