Trajan announces commercial release of HDExaminer PRO v1.0 at ASMS 2026
New software platform improves performance, usability, and mutant analysis capabilities for structural biology and proteomics research
1 Jun 2026Editorial article
Trajan Scientific and Medical (Trajan) has announced the full commercial release of HDExaminer™ PRO v1.0 at ASMS 2026 in the United States, completing the transition of the hydrogen–deuterium exchange mass spectrometry (HDX-MS) software from its first-year beta phase into a fully commercial product within the CHRONECT Studio platform.
The new version is designed to deliver faster, more confident HDX-MS analysis for protein scientists by enhancing workflow efficiency, optimizing performance, and expanding support for mutant analysis.
Advancing HDX-MS workflows for protein scientists
HDExaminer PRO v1.0 is built to support fast, confident HDX-MS analysis and has evolved based on strong beta adoption and extensive user feedback. The software is designed to streamline day-to-day HDX-MS workflows while maintaining its position as one of the fastest HDX-MS analysis environments available.
Version 1.0 introduces usability and performance improvements, including faster result saving and loading, improved project-level performance, and more flexible data management. These enhancements are intended to help structural biologists, proteomics researchers, and pharmaceutical scientists accelerate data interpretation and decision-making in protein characterization studies.
New features for flexible, high-performance HDX-MS analysis
HDExaminer PRO v1.0 introduces several workflow-focused capabilities that enable users to manage complex HDX-MS studies more efficiently. New functionality allows users to add peptides, protein states, timepoints, and new data files directly into existing projects via the project tree structure, supporting iterative experimental design and analysis.
Customizable project color coding improves clarity and organization across complex studies, helping users quickly distinguish between different protein states, conditions, or timepoints. The release also delivers faster result saving and loading, as well as improved performance at the project level, to support large-scale HDX-MS datasets.
This version broadens the analytical scope of the platform. Native support for mutant analysis enables researchers to assign point mutations and immediately visualize them within the software, helping to link sequence changes to structural and functional effects. Unified significance filtering makes it easier to isolate meaningful changes across datasets, supporting more confident interpretation of HDX-MS results.
From Mass Spec Studio to CHRONECT Studio
HDExaminer PRO originated from the Mass Spec Studio software platform acquired by Trajan from the laboratory of Dr. David Schriemer at the University of Calgary. Since the acquisition, the platform has evolved into a core component of Trajan’s CHRONECT Studio portfolio.
CHRONECT Studio is focused on delivering integrated, application-driven analytical workflows for structural biology and proteomics. Within this portfolio, HDExaminer PRO is positioned to support researchers working on protein structure, dynamics, and interactions, including those in pharmaceutical development and academic structural biology.
Embedded collaboration with the University of Calgary
In parallel with the commercial release of HDExaminer PRO v1.0, Trajan continues its research collaboration with the laboratory of Dr. Schriemer at the University of Calgary. This collaboration embeds Trajan within a leading structural biology research environment, creating a direct bridge between academic discovery and real-world application development.
The purpose of the collaboration is to accelerate the translation of complex structural biology methods into scalable, easy-to-use analytical solutions for the protein science community. By working within an active research laboratory, Trajan aims to ensure that CHRONECT Studio workflows, including HDExaminer PRO, are closely aligned with real-world user needs.
A partnership model for co-developing workflows and technologies
The partnership between Trajan and the University of Calgary extends beyond a traditional vendor–laboratory relationship. The two organizations operate as an integrated team, creating a continuous, two-way exchange of expertise.
Working side by side, the team co-develops, tests, and validates new workflows and technologies across software, instrumentation, and consumables within a real-world end-user environment. The collaboration spans practical application development, workflow optimization, and training to accelerate the adoption of emerging structural biology approaches.
Kyle Bachus, VP of Pharma Solutions at Trajan, said, "Together, the release of HDExaminer PRO v1.0 and the collaboration with the University of Calgary reinforce Trajan’s commitment to advancing protein science. Through tightly integrated software, workflow automation, and application-led innovation, we are delivering scalable, high-performance solutions that extend beyond HDX-MS workflows into broader structural biology applications.”
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Frequently asked questions
What is HDExaminer PRO v1.0 and how does it advance hydrogen–deuterium exchange mass spectrometry (HDX-MS) workflows for protein scientists?
HDExaminer PRO v1.0 is Trajan Scientific and Medical’s fully commercial HDX-MS software, released within the CHRONECT Studio platform following a first-year beta phase. It is designed to deliver fast, confident hydrogen–deuterium exchange mass spectrometry analysis by streamlining day-to-day workflows, improving usability and performance, and supporting large-scale datasets.
The software offers faster result saving and loading, improved project-level performance, and more flexible data management, helping structural biologists, proteomics researchers, and pharmaceutical scientists accelerate data interpretation and decision-making in protein characterization studies.
What new features in HDExaminer PRO v1.0 support complex protein characterization and mutant analysis in structural biology and proteomics?
HDExaminer PRO v1.0 introduces workflow-focused capabilities that enable users to manage complex HDX-MS studies more efficiently. Researchers can add peptides, protein states, timepoints, and new data files directly into existing projects via the project tree structure, supporting iterative experimental design and analysis.
Customizable project color coding improves clarity across complex studies by distinguishing protein states, conditions, or timepoints. The software broadens analytical scope with native support for mutant analysis, allowing assignment and immediate visualization of point mutations to link sequence changes with structural and functional effects.
Unified significance filtering helps isolate meaningful changes across datasets, supporting more confident interpretation of HDX-MS results in structural biology and proteomics applications.
How does Trajan’s collaboration with the University of Calgary and the CHRONECT Studio platform strengthen leadership in structural biology, proteomics, and pharmaceutical development?
Trajan’s HDExaminer PRO originated from the Mass Spec Studio platform acquired from the laboratory of Dr. David Schriemer at the University of Calgary, and has since become a core component of the CHRONECT Studio portfolio. CHRONECT Studio delivers integrated, application-driven analytical workflows for structural biology and proteomics, supporting research on protein structure, dynamics, and interactions, including pharmaceutical development and academic structural biology.
The ongoing collaboration with Dr. Schriemer’s internationally recognized laboratory, embeds Trajan in a leading structural biology environment and enables co-development, testing, and validation of workflows and technologies in real-world end-user settings.