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Thermo Fisher Scientific unveils next-generation mass spectrometers at ASMS 2025

Thermo Fisher Scientific

Orbitrap Astral Zoom and Orbitrap Excedion Pro deliver increased speed and sensitivity to set a new performance benchmark for high-resolution, accurate mass spectrometry

2 Jun 2025

Product news

Thermo Fisher Orbitrap Astral Zoom

Thermo Fisher Scientific Inc has launched the Thermo Scientific™ Orbitrap™ Astral™ Zoom mass spectrometer and the Thermo Scientific™ Orbitrap™ Excedion™ Pro mass spectrometer at ASMS 2025 in Baltimore, USA.

Delivering unrivaled analytical performance and speed, the instruments are designed to uncover complex biological processes that could lead to advancements in precision medicine and significant insights for complex diseases like Alzheimer’s and cancer. These Orbitrap innovations enhance Thermo Fisher’s portfolio of industry-leading solutions, delivering a connected and powerful ecosystem that enables the success of customers in proteomics, biopharmaceutical development, and scientific research.

Ultimate performance in life sciences research and discovery

Expanding on the success of the award winning Thermo Scientific Orbitrap Astral mass spectrometer, the Orbitrap Astral Zoom MS delivers unparalleled performance and is engineered to drive the next wave of breakthroughs in scientific research. The instrument enables 35% faster scan speeds, 40% higher throughput, and 50% expanded multiplexing capabilities, delivering higher sensitivity and increased experimental flexibility.

With enhanced analytical coverage, research scientists can now extract richer data from their samples and accelerate transformative discoveries that could shape the future of biopharma innovation.

“The Orbitrap Astral Zoom mass spectrometer will be a paradigm shift for proteomics technology to inspire a new strategy for early detection, early management, and precision oncology,” said Yu-Ju Chen, Ph.D., Distinguished Research Fellow, Institute of Chemistry, Academia Sinica. “With greater depth and coverage, we are able to see more biomarker candidates from the data generated from the Orbitrap Astral Zoom mass spectrometer. These discoveries will mark a very important milestone as we are able to translate proteomics into specific clinical research applications.”

Next-generation mass spectrometry for superior characterization and biopharma development

Building on the sensitivity, resolution and accuracy of Orbitrap technology, the Thermo Scientific Orbitrap Excedion Pro MS offers enhanced performance to accelerate biological drug development. Orbitrap Excedion Pro is the first platform to combine next-generation Orbitrap hybrid mass spectrometry with alternative fragmentation technologies, a technique for efficiently analyzing complex biomolecules.

Researchers can now gain a deeper understanding of biotherapeutics such as monoclonal antibodies (mAbs), accelerating the development of treatments across many areas including cardiology, neurology, and oncology. With enhanced sensitivity, dynamic range, and reliability, the Orbitrap Excedion Pro MS delivers faster, higher-quality, protein and post-translational modification data along with small molecule insights to drive robust biological understandings.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis. BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach. ProteomicsProteomics refers to the analysis of proteins through a variety of different experiments in order to understand structure and functionality. Typical techniques include protein purification and mass spectrometry.

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