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Thermo Fisher Scientific Introduces TraceFinder 1.1 Routine Quantitative LC-MS Software at ASMS 2011

12 Jun 2011
bridget bridget
Laboratory Director

Product news

Thermo Fisher Scientific Inc. today introduced Thermo Scientific TraceFinder 1.1, its latest software for clinical research, forensic toxicology, food safety and environmental testing laboratories performing routine, high-throughput quantitation by LC-MS.

The software retains all of the capabilities of its predecessor and has been expanded to include complete integration with the Thermo Scientific Transcend system. It is also compatible with all Thermo Scientific quantitative mass spectrometry platforms, including the Thermo Scientific Exactive and LTQ family of systems. The software can be seen at Thermo Scientific Booth 110 or the Thermo Scientific hospitality suite at the Hyatt Regency in Centennial Ballroom D during the 59th Annual ASMS Conference on Mass Spectrometry and Allied Topics, from June 5–9 in Denver.

“Our customers asked for easy-to-use software for routine LC-MS quantitation that integrates seamlessly with their front-end system of choice - the Transcend System - and all of the Thermo Scientific quantitative LC-MS systems, including the LTQ series and the Exactive,” said Ian Jardine, vice president of global R&D, Thermo Fisher Scientific. “We enhanced TraceFinder 1.1 specifically to meet these needs, and now customers have one software solution for method development, data acquisition, data processing and report generation that they can use with our Thermo Scientific TSQ Series triple stage quadrupole system, the Exactive, Orbitrap or one of our ion trap systems. This will enable them to significantly improve laboratory productivity.”

The TraceFinder™ software is designed to make routine LC-MS quantitation and targeted analysis simple, fast and productive. The software offers a four-step, workflow-driven method setup and fully automated data acquisition, data processing and reporting. It includes an extensive choice of preconfigured methods and more than 50 report templates, as well as compound data stores for selected reaction monitoring (SRM) experiments in environmental testing, food safety residue analysis, clinical research and forensic toxicology applications. Data review is easy with the ability to specify and report multiple flags. To protect the integrity of analytical data, the software includes a rights-based secure user login system.

The Transcend™ system combines the power of automated online sample preparation and multiplexing to increase throughput without compromising data quality or sensitivity. The unique multiplexing technology of the Transcend system brings the productivity of up to four separate, parallel LC systems to a single mass spectrometer, enabling clinical research, forensic toxicology, food testing and environmental laboratories to achieve a four-fold increase in sample throughput. Thermo Scientific TurboFlow Technology automates sample preparation and can reduce the time spent on this task by up to 95 percent.

Other new products launched at ASMS include:

• EASY-nLC 1000, a new split-free, nano-flow UHPLC system
• Thermo Scientific TSQ Quantum XLS Ultra, its new triple quadrupole gas chromatography-mass spectrometry (GC-MS/MS) system designed to offer best-in-class selectivity, analytical performance and productivity
• Thermo Scientific Velos Pro, with improved quantitative performance, faster scanning, Trap-Higher Energy Collision Dissociation (HCD) and enhanced robustness, the Velos Pro™ mass spectrometer expands the applicability of ion trap workflows.
• Thermo Scientific Q Exactive high-performance benchtop quadrupole-Orbitrap LC-MS/MS

For more information about the TraceFinder 1.1, as well as other new Thermo Scientific products, please visit the Thermo Scientific Booth 110 or the Thermo Scientific hospitality suite at the Hyatt Regency in Centennial Ballroom D. Alternatively, please visit the company article page.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. 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Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Environmental Monitoring and TestingEnvironmental monitoring and testing uses handheld portable analyzers, kits, spectrometers or chromatography systems for air, water, soil, food and other sample testing. Useful features of analyzers such as BOD and COD include portability, easy calibration, automation and sensitivity.  Environmental test kits for pH, water, moisture, etc, should be accurate, sensitive, reliable, fast and easy to use.

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Thermo Fisher Scientific Introduces TraceFinder 1.1 Routine Quantitative LC-MS Software at ASMS 2011