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Thermo Fisher Scientific Introduces New Microarray Substrate

20 Mar 2008

Product news

Thermo Fisher Scientific Inc., the world leader in serving science, announced the introduction of a new, agarose-based microarray substrate for proteomics and discovery, the Thermo Scientific SuperChip™ AB.

Agarose, a substance already familiar to scientists working with proteins, is an economical, protein-friendly medium that significantly reduces the background that can interfere with signal detection of low abundance proteins or peptides. SuperChip AB is an alternative to substrates that produce higher backgrounds, so low-expression molecules stand out.

“Scientists working with agarose in 2-D gels or capillary electrophoresis are aware of its benefits in protein studies,” said Slawek Mielewczyk, Ph.D., senior scientist and project leader for the slides and specialty glass business of Thermo Fisher Scientific. “We’re introducing the SuperChip AB as a lower-background alternative to existing substrates when signal interference could pose a problem. The combination of agarose and our proprietary microarray surface offers the covalent binding properties required for protein studies.”

Thermo Scientific microarray substrates feature the latest chemistries and surface treatment needed to fabricate reliable, consistent microarrays.

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ElectrophoresisElectrophoresis equipment is used to separate mixtures of protein, DNA or RNA, based on their electric charge, size and other physical characteristics, by passing them through a medium such as a polyacrylamide gel, an agarose gel or a capillary tube. Electrophoresis equipment includes horizontal and vertical gel electrophoresis chambers, isoelectric focusing systems, 2D electrophoresis and capillary electrophoresis instruments. Precast gels with a gradient can be used or gels can be hand cast. Samples are run alongside ladders or markers to identify the approximate size of a molecule. Separated proteins and nucleic acids in the gel can be stained or probed with fluorescent markers and then imaged and detected using gel documentation instruments, transilluminators, densitometers and scanners. Find the best electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Thermo Fisher Scientific Introduces New Microarray Substrate