Thermo Fisher Scientific introduces groundbreaking mass spectrometer to revolutionize biological discovery

Thermo Scientific Orbitrap Astral mass spectrometer combines high resolution and speed to accelerate the discovery of new proteins and advance precision medicine

4 Jun 2023
Georgina Wynne Hughes
Editorial Assistant

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Thermo Fisher Scientific Inc. (NYSE: TMO), a world leader in serving science, has unveiled the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer, one of the most significant advancements in mass spectrometry in 15 years. The new Astral analyzer combines fast throughput, high sensitivity and deep proteome coverage to allow researchers worldwide to uncover proteins that previously evaded detection and make breakthrough discoveries more efficiently than ever. Researchers can use this information to identify new clinical biomarkers, reveal diseases earlier and develop new interventions for everything from cardiovascular disease to cancer.

“Continuing our strong track record of high impact innovation, this remarkable advancement will enable key scientific breakthroughs that will allow our customers to develop new, targeted therapies for a range of diseases,” said Marc N. Casper, chairman, president and chief executive officer of Thermo Fisher Scientific. “We are proud to launch this cutting-edge technology as it will meaningfully contribute to the success of researchers around the globe working to make precision medicine a reality.”

Advances in genomics have led to valuable insights into disease. Proteomics expands on this research by adding new understandings of complex and dynamic cellular-level processes that can lead to the development of new drugs and diagnostics that have a material impact on human health.

The new Astral analyzer builds on Thermo Fisher’s proven Orbitrap mass spectrometry platform with novel technology to deliver up to two times deeper proteome coverage and up to four times more throughput compared to current mass spectrometers.

“One of the biggest challenges we face studying the human proteome is having too many samples to measure and not enough time,” said Michael MacCoss, professor of genome sciences at the University of Washington. “The Orbitrap Astral mass spectrometer is a true gamechanger, offering an unrivaled combination of sensitivity, dynamic range and speed that doesn’t compromise accurate and precise quantitation. With this instrument, we can deliver on the promise of precision medicine much sooner.”

Thermo Fisher will showcase the Orbitrap Astral mass spectrometer at the American Society for Mass Spectrometry (ASMS) annual conference from June 3-8, 2023, in Houston, Texas, at the George R. Brown Convention Center and at the Hilton Americas-Houston Lanier Grand Ballroom A, B, C. The Orbitrap Astral mass spectrometer together with additional new products being introduced at ASMS create a next generation, end-to-end solution for proteomics that enables the analysis of large cohorts, powering the study of proteomics at a scale previously only obtainable by genomics.

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Thermo Scientific Orbitrap Astral mass spectrometer

Thermo Fisher Scientific

The Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer is powered by the synergy of a high-resolution quadrupole mass filter, Thermo Scientific™ Orbitrap™ analyzer and novel Thermo Scientific™ Astral™ analyzer to achieve unsurpassed performance and experimental flexibility. The combination of the three mass analyzers enables the rapid acquisition of exceptional quality high resolution accurate mass (HRAM) full scan and MS/MS spectra with high sensit

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Precision MedicinePrecision medicine refers to the idea of customized healthcare, where medical decisions and treatments are tailored to the individual patient. Molecular diagnostics, companion diagnostics and Next Generation Sequencing (NGS) play a pivotal role in this approach. ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis. Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.
Thermo Fisher Scientific introduces groundbreaking mass spectrometer to revolutionize biological discovery