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Thermo Fisher Scientific Extends Breakthrough LTQ Orbitrap Platform with Two New Mass Spectrometers

3 Jun 2007

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Thermo Fisher Scientific Inc., the world leader in serving science, has extended its innovative range of Thermo Scientific life science hybrid mass spectrometry with the introduction of two new instruments, the LTQ Orbitrap Discovery™ and the LTQ Orbitrap XL™.

Offering outstanding mass accuracy, resolving power, dynamic range and sensitivity, these hybrid instruments offer significant advantages over Q-TOF instruments, both in terms of superior protein identification capabilities and increased sensitivity. The new LTQ Orbitrap instruments are ideally suited for research performed in commercial and academic laboratories for pharmaceutical, metabolomics, proteomics and biomarker discovery. The new instruments will be displayed at the downtown Marriott Ballroom 5, daily from 7:00-10:00 PM during the 55th Annual ASMS Conference on Mass Spectrometry.

The new Thermo Scientific LTQ Orbitrap Discovery provides accessibility to the breakthrough LTQ Orbitrap technology for a wide range of labs. The robust, powerful and cost-effective system is ideally suited for general proteomics and metabolism applications, offering a superior alternative to Q-TOF systems. Featuring high resolution and excellent accurate mass capabilities, this hybrid LC-MS system achieves high throughput label-free profiling for differential expression while the MSn capability makes the instrument ideal for small molecule characterization and structural elucidation. The LTQ Orbitrap Discovery is a highly sensitive system with up to 30K resolution power and an exceptional scan rate, enabling the separation of trace level, isobaric analytes.

The new Thermo Scientific LTQ Orbitrap XL is the ultimate protein identification and biomarker discovery platform featuring unsurpassed sensitivity in MS and MSn, rapid scan rate, high mass accuracy and up to 100K resolution power. Based on the highly successful LTQ Orbitrap platform, this instrument provides unrivalled performance and flexibility. The LTQ Orbitrap XL features the new HCD octapole collision cell for increased flexibility in MS/MS fragmentation applications including iTRAQ™ based peptide quantitation, PTM analysis, de novo sequencing and metabolomics research. This proteomics platform is also compatible with, and upgradeable to use the Electron Transfer Dissociation (ETD) option for controlled dissociation of peptides and proteins, making this instrument indispensable for advanced proteomics research.

For more information about the new Thermo Scientific LTQ Orbitrap Discovery and LTQ Orbitrap XL mass spectrometers, visit booth #54 at the ASMS conference, Indiana, June 3-7.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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Thermo Fisher Scientific Extends Breakthrough LTQ Orbitrap Platform with Two New Mass Spectrometers