Thermo Fisher Scientific expands Orbitrap innovation for research, biopharma and applied testing at ASMS 2026

Thermo Fisher Scientific Inc., is showcasing its Thermo Scientific™ Orbitrap™ mass spectrometry platforms, AI-enabled software and integrated workflows at the American Society for Mass Spectrometry (ASMS) 2026 Conference in San Diego, USA, from May 31–June 4.

The company is introducing new high-resolution Orbitrap mass spectrometers, intelligent data analysis tools and end-to-end workflows that help research, biopharmaceutical and applied testing laboratories worldwide generate deeper biological insight, make more confident drug development decisions and deliver faster, regulatory-ready contaminant testing.

Scaling Orbitrap mass spectrometry across complex scientific markets

Across research, biopharma and applied testing, scientists are working with increasingly complex samples, expanding data sets and growing pressure to deliver confident answers faster. Thermo Fisher Scientific is addressing these challenges by bringing its flagship Orbitrap technology to more scientific decision points.

The expanded portfolio combines high-resolution accurate-mass (HRAM) Orbitrap platforms with integrated chromatography, sample preparation and AI-enabled software. These complete solutions are designed to advance discoveries in complex biology, accelerate the development of new medicines and strengthen testing for food, air and water quality.

New Orbitrap platforms and AI-enabled software at ASMS 2026

Thermo Fisher Scientific is introducing three new Thermo Scientific Orbitrap platforms at ASMS 2026, extending high-resolution mass spectrometry and end-to-end solutions to more decision points across research, biopharmaceutical and applied markets:

• Thermo Scientific Orbitrap Tribrid Apex Mass Spectrometer
• Thermo Scientific Orbitrap Excedion Mass Spectrometer
• Thermo Scientific Orbitrap Exploris GC S Mass Spectrometer

These instruments are supported by new AI-enabled software capabilities, including Thermo Scientific Proteoform Studio Software, Thermo Scientific Proteome Discoverer™ 3.4 Software and Thermo Scientific BioPharma Finder™ 5.5 Software, as well as technologies from the recent acquisitions of MSAID and Proteinaceous. Together, these solutions help laboratories speed proteomics analysis, spectral interpretation and advanced protein characterization.

Thermo Fisher Scientific is also highlighting targeted mass spectrometry systems for regulated workflows, including the Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer, the Thermo Scientific Orbitrap Exploris EFOX Mass Detector and the Thermo Scientific TSQ Altis Plus EFOX Triple Quadrupole Mass Spectrometer.

Clearer disease insights in complex biology research

The Thermo Scientific Orbitrap Tribrid Apex Mass Spectrometer (MS) is designed to give researchers a more powerful way to study challenging biological samples on a single platform. As Thermo Fisher Scientific’s most versatile and highest-performing Orbitrap Tribrid system, the Orbitrap Tribrid Apex MS brings multiple capabilities together in one instrument, including three mass analyzers, a new infrared laser option for alternative fragmentation and Thermo Scientific Direct Mass Technology™ Mode.

These combined capabilities help researchers obtain clearer answers from complex biology earlier in the discovery process, supporting applications such as proteomics, structural biology and intact protein analysis.

Thermo Fisher Scientific is also expanding its software capabilities across proteomics, spectral analysis and advanced protein characterization:

• MSAID and Proteinaceous, Thermo Fisher Scientific’s recent software acquisitions, deliver smarter proteomics workflows that speed analysis and streamline connectivity. MSAID brings AI-driven proteomics and machine learning expertise, while Proteinaceous adds top-down and native mass spectrometry bioinformatics.
• Thermo Scientific Proteoform Studio Software provides researchers with a streamlined proteomics workflow from acquisition through reporting, including Direct Mass Technology analysis for deeper characterization of proteoforms.
• Thermo Scientific Proteome Discoverer 3.4 Software helps scientists manage more proteomics workflows in one place, making it easier to analyze additional data with greater flexibility, speed and coverage.

Greater confidence in biopharma and pharma drug development

For pharmaceutical and biopharmaceutical laboratories, Thermo Fisher Scientific is unveiling the Thermo Scientific Orbitrap Excedion Mass Spectrometer, an Orbitrap platform designed to reduce performance tradeoffs in drug development.

Built for applications ranging from drug metabolism studies to oligonucleotide and peptide analysis, the Orbitrap Excedion MS offers enhanced dynamic range (eDR) that detects three to five times more compounds in complex samples and delivers more reproducible results across larger studies. For the first time, laboratories can upgrade to Orbitrap Excedion Pro MS without replacing their instrument, expanding analytical power while minimizing cost and disruption to ongoing work.

To support end-to-end biopharmaceutical development workflows, Thermo Fisher Scientific is also introducing complementary innovations:

• Thermo Scientific Vanquish Amplify UHPLC Systems use an inert, metal-free sample flow path engineered to minimize adsorption and secondary interactions. This helps scientists analyze sensitive biological molecules, such as short oligonucleotides, with less sample loss, better reproducibility and greater confidence in results from method development through quality control.
• Thermo Scientific SurePac RP MDi Columns are purpose-built for oligonucleotide, mRNA and protein therapeutic analysis, helping improve recovery, separation and reproducibility under demanding conditions.
• Thermo Scientific SMART Digest OligoSelect Kit simplifies sample preparation for oligonucleotide bioanalysis with a single, streamlined workflow that reduces time and cost.
• Thermo Scientific BioPharma Finder 5.5 Software helps scientists process complex top-down mass spectrometry data from the latest Thermo Fisher Scientific instruments faster while maintaining consistent results.

As drug candidates move further through development, laboratories require robust workflows for regulated bioanalysis and QA/QC. For these later-stage needs, Thermo Fisher Scientific will also showcase the Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer.

This system helps scientists accelerate drug development by measuring samples 15% faster and running more than twice as long between maintenance events for complex matrices such as plasma.

Regulatory-ready results for food and environmental safety

For environmental, water and food safety laboratories, Thermo Fisher Scientific is expanding its Orbitrap and targeted mass spectrometry workflows to support high-resolution screening and reliable quantitation of regulated and emerging contaminants.

The Thermo Scientific Orbitrap Exploris GC S Mass Spectrometer is a high-resolution gas chromatography–mass spectrometry (GC-MS) platform designed to modernize dioxin and persistent organic pollutants (POPs) analysis for environmental and food safety testing. As regulations evolve and contaminant lists expand, the Orbitrap Exploris GC S MS delivers regulatory-ready, ultra-trace results with the sensitivity and resolving power needed for confident, reliable testing.

With more than twice the resolution of many existing systems, the Orbitrap Exploris GC S MS also helps laboratories identify emerging contaminants without additional instruments, saving time and reducing complexity in high-stakes public health or environmental testing.

Thermo Fisher Scientific will also showcase:

• Thermo Scientific Orbitrap Exploris EFOX Mass Detector for high-resolution screening of per- and polyfluoroalkyl substances (PFAS), pesticides and related contaminants.
• Thermo Scientific TSQ Altis Plus EFOX Triple Quadrupole Mass Spectrometer for reliable, high-throughput quantitation of targeted analytes.

Together with Thermo Fisher Scientific’s application expertise and service, these systems help environmental, water and food safety laboratories detect known and emerging contaminants faster, respond to potential risks sooner and make more confident public health decisions.

AI-enabled technology for faster interpretation

To help laboratories keep pace with growing data volumes and complexity, Thermo Fisher Scientific is integrating AI-enabled technology and advanced bioinformatics across its Orbitrap ecosystem.

New software capabilities, including Thermo Scientific Proteoform Studio, Thermo Scientific Proteome Discoverer 3.4 and Thermo Scientific BioPharma Finder 5.5, work alongside the acquired technologies from MSAID and Proteinaceous to:

• Accelerate proteomics analysis and spectral interpretation.
• Enhance top-down and native mass spectrometry data processing.
• Improve connectivity across instruments, workflows and reporting.

These tools are designed to help scientists move from raw data to actionable insight more quickly, supporting applications from complex proteome characterization to detailed analysis of biotherapeutics.

Supporting scientists across research, biopharma and applied markets

The expanded Orbitrap portfolio and supporting workflows are built to help customers reduce tradeoffs, simplify complex analysis and deliver clearer, more actionable results across research, drug development and environmental testing.

By combining high-resolution Orbitrap mass spectrometry, targeted triple quadrupole systems, inert-flow-path chromatography, streamlined sample preparation and AI-enabled software, Thermo Fisher Scientific aims to help laboratories:

• Generate deeper biological insight in complex disease research.
• Make more confident decisions throughout biopharmaceutical and pharmaceutical development.
• Deliver faster, regulatory-ready contaminant testing for food, water and environmental samples.

Instruments are for general laboratory use only. Not for diagnostic purposes.

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