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Thermo Fisher Scientific and Gentel Biosciences Collaborate to Introduce a NEW 96 Well Multiplex Platform

23 Apr 2008

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Thermo Fisher Scientific Inc., the world leader in serving science, and Gentel® Biosciences, a protein microarray life sciences company, today announced the two companies have completed the first stage of a collaboration to shift microarrays to a new 96 well configuration. This new patent-pending product will evolve the current microarray offerings toward an “ELISA-like” format to increase the speed and volume of multiplex applications. The new platform conforms to the SBS microplate standard and is amenable to the automated processing of thousands of samples per day.

Thermo Fisher Scientific offers the platform under the Thermo Scientific SmartPlex™ brand name with a range of microarray chemistry configurations including aminosilane and epoxysilane. Gentel Biosciences offers the platform engineered with a proprietary ultra-thin nitrocellulose surface chemistry under the APiX™96 brand name. Gentel has also initiated development of content-based research kits including quantitative multiplex immunoassays, antibody and antigen arrays in the 96-well format.

“The SmartPlex platform uses the superior binding surface of glass to enable a range of widely accepted surface chemistries to be used reliably in multiplex applications in a traditional microtiter-plate format,” said David Moore, Director of Research and Development for the slides and specialty glass business of Thermo Fisher Scientific.

“ELISAs have long been the ‘gold standard’ for protein measurements. Now that multiplex immunoassays have come of age, higher throughput configurations of the technology are a natural step in providing the next generation of analytical tools for protein measurements,” said Randy Durnell, Vice President of Commercial Operations at Gentel.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.

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Thermo Fisher Scientific and Gentel Biosciences Collaborate to Introduce a NEW 96 Well Multiplex Platform