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The TV400-DGGE denaturing gradient gel electrophoresis system is a cost-effective solution for researchers studying mutations and DNA polymorphisms critical in disease aetiology and genetic diversity. Designed primarily for parallel denaturing gradient gel electrophoresis (DGGE), where electrophoresis and the denaturing gradient run in the same direction, the TV400-DGGE has a maximum 96-sample throughput compatible with standard microplates and thermal cycler blocks. TV400-DGGE Denaturing Gradient Gel Electrophoresis System Features: Maximum 96-sample throughput - using two 48-sample combs – allows samples to be transferred quickly and easily to the each gel from standard 96- well microplates or thermal cycler blocks. Large format - 20.5 x 20cm glass plates allow gradient gels to be poured containing wider ranges of denaturant concentration, maximising sensitivity and resolution. 100ml gradient mixer - used with the new-style TV400-GRM and casting base to make two 1mm parallel denaturing gradient gels. Formamide, urea and acrylamide available – to pour denaturing gradient gels. Can also be adapted for constant denaturing gel electrophoresis (CDGE) - if the denaturant concentration required for partial melting of the DNA target sequence is already known.

Fast, high throughput microplate compatible electrophoresis The VG-FAST96 high throughput Vari-gel MAXI system is the latest addition to the Scie-Plas Vari-gel Range, providing a swift and simple solution for the screening and analysis of up to 96 single-strand polymorphisms (SSPs) following PCR amplification in 96-well microplates. A single gel tray with UV-fluorescent numbering allows up to 96 SSPs to loaded directly onto the tray, 8 at a time by multi-channel pipette, so that each SSP is automatically numbered for gel documentation, simplifying post-electrophoretic analysis.This unit is ideal for use with 96-well microtitre plates or or the 96-well blocks of the Techne TC412 and TC512 thermal cyclers which are also available through Scie-Plas.VG-FAST96 High Throughput Vari-gel MAXI System Features: Single gel tray with fluorescent numbering - allows up to 96 SSPs to be loaded directly onto the tray, so that each SSP is automatically numbered for gel photography, simplifying postelectrophoretic analysis 6 comb slots - positioned at 25mm intervals along the gel tray allow SSPs to be separated in less than 30 minutes using the appropriate running conditions (see Technical Specification) Six 17-sample combs - with each marker lane positioned centrally - enables SSPs to be loaded onto the gel quickly, 8 at a time by multi-channel pipette Compact tank - reduces the buffer volume required to cover the gel, providing greater control over the voltage gradient and run-time Robust acrylic casting tray – Uvtransparent for visualisation with fluorescent numbering for SNP recognition and traceability Ideal for use - either with 96-well microtitre plates or 96-well blocks Buffer recirculation ports - may be connected to a peristaltic pump for buffer recirculation during electrophoresis