Subvisible particles – Why don’t I just filter my biologic samples?
9 May 2025Filtration of a therapeutic is often cited as a key method to remove particles generated during the manufacturing process. While filtration removes preformed particles, including subvisible particles (SVPs), it does not account for the inherent instability of biologic samples, and thus subvisible aggregates can be generated over time even after filtration.
Explore how Aura® and Backgrounded Membrane Imaging (BMI) was used to explore the effect of filtration on three different biologic formulations. Plus, discover how Aura was able to provide a rapid long-term stability assessment via a low volume, high-throughput assay.
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Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.FiltrationFiltration and microfiltration are used to separate solids, particulates or large molecules from fluids (liquid or gases) in order to purify the filtrate. Explore a range of filter formats, including filter paper, plates and membranes for your separation needs. While larger particulates may be separated by gravity filtration, smaller particulates may require additional force for timely separation. Microfiltration equipment includes vacuum filters, as well as positive pressure, crossflow and centrifugal filtration devices. Find the best filtration products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.