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SelectScience Virtual Biopharmaceuticals Summit: a round up

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The SelectScience Virtual Biopharmaceuticals Summit was an interactive forum for scientists and manufacturers to share cutting-edge technology solutions for biopharmaceuticals research and development.

6 Dec 2022
Blake Forman
Content Creator

Editorial article

SelectScience Virtual Biopharmaceuticals Summit 2022 logo

The SelectScience® Virtual Biopharmaceuticals Summit took place on November 22, in partnership with BioPhorum. The free-to-attend online event offered an interactive forum for scientists and manufacturers to connect, highlight the latest research, and share cutting-edge technology solutions for biopharmaceuticals research and development.

The Summit sessions took place in two concurrent tracks with Track 1 covering a range of topics in Cell Line Development and Gene Therapy, while Track 2 focused on Bioanalysis Techniques.

Paul Anderson (Director, Biologics Discovery Automation, Eli Lilly) was the keynote speaker on Track 1 and presented on Single cell antibody discovery using 'Islands of automation'. There were further talks covering cell line development and gene therapy from a broader perspective including how IT can support cell and gene therapies, as well as the validation challenges. Other presentations focused on the applications, challenges and advancements in the field such as applying a matrix approach for potency assay development for in vivo and ex vivo gene therapies, release specifications for plasmids and master cell banks used in gene therapy, and analysis of critical quality attributes of adeno-associated viruses.

Andrew Mahan (Associate Director, Janssen: Pharmaceutical Companies of Johnson & Johnson) was the keynote speaker on Track 2 on Bioanalysis Techniques and presented on Semi-targeted spent media LC-MS assay: Assuring product quality during cell line development for biologics. With ongoing regulatory updates in the bioanalytical landscape, it was insightful to hear the resulting practical implications within laboratories with talks on Pharma compliance, ligand binding assay validation requirements and strategies, as well as the use of biolayer interferometry as an alternative to surface plasmon resonance in a biopharma regulated environment.

Presentations on recent advances in oligo purity and sequence determination by LCMS, developing methods for biosimilarity studies of therapeutic monoclonal antibodies, and a mid-down strategy for the mass spectrometric sequencing of progressively larger nucleic acids, highlighted the challenges and technological developments in bioanalytical laboratories associated with the constantly growing number of modalities for analysis.

It was encouraging to see the continued discussions on the science and the technologies between attendees and speakers following the talks through the Q&A sessions, and in the dedicated networking spaces provided such as the chatting feature and special connect area.

The Summit also included a Poster Hall through with all posters available for download, showcasing some of the most recent research:

  • Petra Bennington and colleagues presented on ‘Industry approaches for implementation of ready to use (RtU) cells in bioassays’
  • Sylvain Demanze and colleagues presented on ‘Automating analytical data batch-processing in Drug Discovery with Mnova Gears’
  • Aliasgar Shahiwala presented on ‘Quality by Design Approach in development of biologics and biosimilars’
  • Bayan Alkhawaja and Andrew G Watts presented on ‘Vectorized conjugates of monoclonal antibodies: Diagnostic and therapeutic applications’.

There were plenty of topical resource materials and videos available through the Summit platform, including eBooks, application notes and vendor resources on products of interest to the community, which attendees were able to add to their virtual ‘Swag Bags’ and forward to their emails for later use. The virtual Exhibit Hall also hosted booths with several manufactures present enabling attendees to view and link through to their latest product and technologies.

Overall, the SelectScience Virtual Biopharmaceuticals Summit offered an interactive space for scientists and manufacturers to share, collaborate and discuss technological solutions for biopharmaceuticals research and development. If you were not able to attend on the day, you can access the presentations on demand.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. 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